温带噬菌体
Temperate Phages of .
机构信息
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
出版信息
Microbiol Spectr. 2019 Sep;7(5). doi: 10.1128/microbiolspec.GPP3-0058-2018.
Abstract
Most isolates carry multiple bacteriophages in their genome, which provide the pathogen with traits important for niche adaptation. Such temperate phages often encode a variety of accessory factors that influence virulence, immune evasion and host preference of the bacterial lysogen. Moreover, transducing phages are primary vehicles for horizontal gene transfer. Wall teichoic acid (WTA) acts as a common phage receptor for staphylococcal phages and structural variations of WTA govern phage-host specificity thereby shaping gene transfer across clonal lineages and even species. Thus, bacteriophages are central for the success of as a human pathogen.
摘要
大多数 菌株的基因组中携带多种噬菌体，这些噬菌体为病原体提供了适应小生境的重要特征。这种温和噬菌体通常编码多种辅助因子，影响细菌溶源体的毒力、免疫逃避和宿主偏好。此外，转导噬菌体是水平基因转移的主要载体。壁磷壁酸（WTA）是葡萄球菌噬菌体的共同受体，WTA 的结构变异决定了噬菌体-宿主的特异性，从而塑造了跨克隆谱系甚至物种的基因转移。因此，噬菌体是 作为人类病原体成功的关键。
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