大鼠嗜碱性白血病细胞上免疫球蛋白E的受体：配体结合对受体表达的影响。
The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression.
作者信息
Furuichi K, Rivera J, Isersky C
出版信息
Proc Natl Acad Sci U S A. 1985 Mar;82(5):1522-5. doi: 10.1073/pnas.82.5.1522.
Abstract
We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate receptors at the surface and thus the apparent amount of cell-associated IgE continued to increase. The results obtained suggest that, in the presence of IgE, the elimination of the receptor from the surface was halted or slowed significantly (approximately equal to 80%) while insertion into the membrane of previously synthesized receptor continued.
摘要
我们评估了配体结合对大鼠嗜碱性白血病（RBL）细胞上IgE受体表达的影响。RBL细胞在存在或不存在131I标记的IgE的情况下培养，并且有时也用125I进行表面标记。我们发现，在IgE存在下培养的细胞继续在表面积累受体，因此细胞相关IgE的表观量持续增加。所得结果表明，在IgE存在下，表面受体的消除停止或显著减慢（约80%），而先前合成的受体继续插入膜中。
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