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Red blood cell distribution width-to-platelet ratio as a disease activity-associated factor in systemic lupus erythematosus.红细胞分布宽度与血小板比值作为系统性红斑狼疮疾病活动相关因素
Medicine (Baltimore). 2018 Sep;97(39):e12342. doi: 10.1097/MD.0000000000012342.
2
The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis.中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值在检测早发型新生儿败血症中的价值
J Pediatr Hematol Oncol. 2018 May;40(4):e229-e232. doi: 10.1097/MPH.0000000000001059.
3
Systematic review and meta-analysis of the prognostic value of preoperative platelet-to-lymphocyte ratio in patients with urothelial carcinoma.尿路上皮癌患者术前血小板与淋巴细胞比值预后价值的系统评价与荟萃分析
Oncotarget. 2017 Sep 22;8(53):91694-91702. doi: 10.18632/oncotarget.21162. eCollection 2017 Oct 31.
4
Predictive value of pre-operative inflammation-based prognostic scores (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-eosinophil ratio) in testicular sperm extraction: a pilot study.术前炎症相关预后评分(中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和单核细胞与嗜酸性粒细胞比值)对睾丸精子提取术的预测价值:一项初步研究。
Andrology. 2017 Nov;5(6):1100-1104. doi: 10.1111/andr.12417. Epub 2017 Oct 9.
5
Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Red Blood Cell Distribution Width-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency.中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值及红细胞分布宽度与血小板比值用于诊断卵巢早衰的评估
J Family Reprod Health. 2016 Dec;10(4):211-216.
6
Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio?精液参数与中性粒细胞与淋巴细胞比值或血小板与淋巴细胞比值之间存在关联吗?
World J Mens Health. 2017 Apr;35(1):51-56. doi: 10.5534/wjmh.2017.35.1.51.
7
Impact of Inflammation on Male Reproductive Tract.炎症对男性生殖道的影响
J Reprod Infertil. 2015 Jul-Sep;16(3):123-9.
8
Red cell distribution width to platelet ratio: new and promising prognostic marker in acute pancreatitis.红细胞分布宽度与血小板比值:急性胰腺炎中新的且有前景的预后标志物。
World J Gastroenterol. 2014 Oct 21;20(39):14450-4. doi: 10.3748/wjg.v20.i39.14450.
9
Unexplained infertility patients have increased serum IL-2, IL-4, IL-6, IL-8, IL-21, TNFα, IFNγ and increased Tfh/CD4 T cell ratio: increased Tfh and IL-21 strongly correlate with presence of autoantibodies.不明原因不孕症患者血清白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-21(IL-21)、肿瘤坏死因子α(TNFα)、干扰素γ(IFNγ)升高,滤泡辅助性T细胞/CD4 T细胞比值升高:滤泡辅助性T细胞和IL-21升高与自身抗体的存在密切相关。
Immunol Invest. 2015;44(2):164-73. doi: 10.3109/08820139.2014.932377. Epub 2014 Jul 17.
10
Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells.白细胞介素 6 通过抑制蛋白降解或激活支持细胞中磷酸化的 ERK 破坏血睾屏障。
Sci Rep. 2014 Mar 3;4:4260. doi: 10.1038/srep04260.

精液参数异常与中性粒细胞-淋巴细胞比值、血小板-淋巴细胞比值及红细胞分布宽度-血小板比值之间是否存在关联?

Are There Any Relationships Between Abnormal Seminal Parameters and Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Red Blood Cell Distribution-Platelet Ratio?

作者信息

Öztekin Ünal, Caniklioğlu Mehmet, Sarı Sercan, Selmi Volkan, Gürel Abdullah, Caniklioğlu Ayşen, Işıkay Levent

机构信息

Urology, Bozok University Faculty of Medicine, Yozgat, TUR.

Biochemistry, Bozok University Faculty of Medicine, Yozgat, TUR.

出版信息

Cureus. 2019 Jul 25;11(7):e5242. doi: 10.7759/cureus.5242.

DOI:10.7759/cureus.5242
PMID:31565640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6759139/
Abstract

Objective The aim of this study is to determine the relationship between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and red blood cell distribution width (RDW)/platelet ratio (RPR) values, which are pro-inflammatory markers, with abnormal sperm parameters, and to evaluate their availability as predictive markers. Materials and methods A total of 160 patients, 80 of whom were the control group, formed with match-pair analysis (Group 1), and 80 patients with abnormal sperm analysis, who met the study criteria (Group 2), were included in the study. Complete blood count results were recorded. NLR, PLR, and RPR values were calculated using hematological parameters, and a comparison was made between the two groups. Results The mean age was 31.23 ± 5.1 years in Group 1 and 31.33 ± 6.4 years in Group 2. NLR values were 1.84 ± 0.57-1.87 ± 0.65 (P =0.77), PLR values were 105.42 ± 23.89-111.42 ± 34.54 (P = 0.62) and RPR values were 0.05 ± 0.009-0.05 ± 0.01 (P =0.45), respectively. There was no statistically significant difference between the groups. Conclusions We investigated whether NLR, PLR, and RPR results can be used as a predictive marker on abnormal sperm parameters. We do not recommend the use of these parameters as a predictive marker.

摘要

目的 本研究旨在确定作为促炎标志物的中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)以及红细胞分布宽度(RDW)/血小板比值(RPR)与异常精子参数之间的关系,并评估它们作为预测标志物的可用性。材料与方法 本研究共纳入160例患者,其中80例通过配对分析组成对照组(第1组),另外80例符合研究标准的精子分析异常患者(第2组)。记录全血细胞计数结果。使用血液学参数计算NLR、PLR和RPR值,并对两组进行比较。结果 第1组的平均年龄为31.23±5.1岁,第2组为31.33±6.4岁。NLR值分别为1.84±0.57 - 1.87±0.65(P = 0.77),PLR值分别为105.42±23.89 - 111.42±34.54(P = 0.62),RPR值分别为0.05±0.009 - 0.05±0.01(P = 0.45)。两组之间无统计学显著差异。结论 我们研究了NLR、PLR和RPR结果是否可作为异常精子参数的预测标志物。我们不建议将这些参数用作预测标志物。