Kim So Young, Oh Dong Jun, Park Bumjung, Park Il-Seok, Choi Hyo Geun
Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam.
Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul Hospital.
Medicine (Baltimore). 2019 Sep;98(38):e17203. doi: 10.1097/MD.0000000000017203.
The study aimed to expand previous data regarding an association between asthma and appendectomy in children compared with the population of all ages.The Korean Health Insurance Review and Assessment Service-National Sample Cohort from 2002 through 2013 was used. In all, 22,030 participants who underwent appendectomy were matched for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 88,120 participants who were included as a control group. In both the appendectomy and control groups, previous history of asthma was investigated. Appendectomy for appendicitis was identified based on a surgical code (International Classification of Disease-10 [ICD-10]: K35). Asthma was classified using an ICD-10 code (J45 and J46) and medication history. The crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of asthma for appendectomy were analyzed using conditional logistic regression analysis. Subgroup analyses were conducted according to age and sex.Approximately 15.2% (3358/22,030) of individuals in the appendectomy group and 13.3% (11,749/88,120) of those in the control group had asthma (P < .001). The appendectomy group demonstrated a higher adjusted odds of asthma than the control group (adjusted OR 1.18, 95% CI 1.13-1.23, P < .001). This result was consistent in the subgroups divided according to age and sex.The odds for asthma were higher in the appendectomy group than in the control group.
该研究旨在扩展以往关于儿童哮喘与阑尾切除术之间关联的数据，并与所有年龄段人群进行比较。研究使用了韩国健康保险审查与评估服务中心2002年至2013年的全国样本队列。总共22030名接受阑尾切除术的参与者，在年龄、性别、收入、居住地区、高血压、糖尿病和血脂异常方面与88120名作为对照组的参与者进行了匹配。在阑尾切除术组和对照组中，均调查了哮喘病史。基于手术编码（国际疾病分类第10版[ICD - 10]：K35）确定阑尾炎的阑尾切除术。使用ICD - 10编码（J45和J46）及用药史对哮喘进行分类。使用条件逻辑回归分析阑尾切除术与哮喘的粗比值比（OR）和调整后比值比以及95%置信区间（CI）。根据年龄和性别进行亚组分析。阑尾切除术组中约15.2%（3358/22030）的个体患有哮喘，对照组中这一比例为13.3%（11749/88120）（P<0.001）。阑尾切除术组哮喘的调整后比值高于对照组（调整后OR 1.18，95%CI 1.13 - 1.23，P<0.001）。这一结果在按年龄和性别划分的亚组中是一致的。阑尾切除术组哮喘的比值高于对照组。
