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IFN Therapy in Airway Disease: Is Prophylaxis a New Approach in Exacerbation Prevention?

作者信息

Johnston Sebastian L

机构信息

National Heart and Lung InstituteImperial College LondonLondon, United Kingdomand.

Asthma UK Centre in Allergic Mechanisms of AsthmaLondon, United Kingdom.

出版信息

Am J Respir Crit Care Med. 2020 Jan 1;201(1):9-11. doi: 10.1164/rccm.201909-1850ED.

DOI:10.1164/rccm.201909-1850ED
PMID:31577905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6938143/
Abstract
摘要

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本文引用的文献

1
Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies.呼吸道病毒感染期间 IFN-β 反应的动力学。治疗策略的见解。
Am J Respir Crit Care Med. 2020 Jan 1;201(1):83-94. doi: 10.1164/rccm.201901-0214OC.
2
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.转录组网络鉴定儿童病毒和非病毒哮喘恶化的机制。
Nat Immunol. 2019 May;20(5):637-651. doi: 10.1038/s41590-019-0347-8. Epub 2019 Apr 8.
3
Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease.气道葡萄糖在慢性阻塞性肺疾病患者细菌感染中的作用。
J Allergy Clin Immunol. 2018 Sep;142(3):815-823.e6. doi: 10.1016/j.jaci.2017.10.017. Epub 2018 Jan 5.
4
Colds as predictors of the onset and severity of COPD exacerbations.感冒作为慢性阻塞性肺疾病急性加重发作和严重程度的预测指标。
Int J Chron Obstruct Pulmon Dis. 2017 Mar 10;12:839-848. doi: 10.2147/COPD.S127146. eCollection 2017.
5
Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile.Toll样受体7在重症哮喘中表达降低，并与微小RNA谱改变有关。
Am J Respir Crit Care Med. 2016 Jul 1;194(1):26-37. doi: 10.1164/rccm.201502-0280OC.
6
Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium.抗病毒应激颗粒和干扰素-β增强体形成受损会增加慢性阻塞性肺疾病上皮细胞对流感感染的易感性。
Am J Respir Cell Mol Biol. 2016 Jul;55(1):117-27. doi: 10.1165/rcmb.2015-0306OC.
7
Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.慢性阻塞性肺疾病急性加重期的氧化应激、亚硝化应激与组蛋白去乙酰化酶-2活性
Chest. 2016 Jan;149(1):62-73. doi: 10.1378/chest.14-2637. Epub 2016 Jan 6.
8
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.吸入式干扰素-β对病毒感染所致哮喘症状恶化的影响。一项随机试验。
Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.
9
EAACI position statement on asthma exacerbations and severe asthma.欧洲变应性反应和临床免疫学会关于哮喘加重和重症哮喘的立场声明
Allergy. 2013 Dec;68(12):1520-31. doi: 10.1111/all.12275. Epub 2013 Nov 6.
10
Rhinovirus-induced interferon production is not deficient in well controlled asthma.鼻病毒诱导的干扰素产生在良好控制的哮喘中并不缺乏。
Thorax. 2014 Mar;69(3):240-6. doi: 10.1136/thoraxjnl-2012-202909. Epub 2013 Oct 14.