Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University.
The Nippon Synthetic Chemical Industry Co., Ltd.
Biol Pharm Bull. 2019;42(10):1753-1760. doi: 10.1248/bpb.b19-00482.
The use of three-dimensional (3D) printing technology is expanding in various fields. The application of 3D printing is expected to increase in the pharmaceutical industry after 3D-printed tablets were approved by the U.S. Food and Drug Administration (FDA). Fused deposition modeling (FDM), a type of 3D printing, has been extensively studied for the manufacturing of tablets. A drug-loaded polymer filament, the ink of FDM 3D printers, can be prepared using the hot melt extrusion method or a simple drug-soaking method. In the present study, we investigate the influence of the experimental conditions on the loading of curcumin (model drug with fluorescence) into a polyvinylalcohol polymer filament using the soaking method. We show that organic solvent type (isopropanol, methanol, acetone, and ethanol), temperature (25 and 80°C), and drug concentration (2-333 mg/mL) greatly affect drug loading. Around 5% curcumin can be incorporated into the polyvinylalcohol filament using the soaking method. The drug dissolution from 3D-printed tablets depends on the drug content in the polymer filament. The incorporation of a higher amount of curcumin, which has poor water solubility, greatly delays drug dissolution. These results provide useful information on the preparation of 3D-printed tablets using a drug-loaded polymer filament obtained with the soaking method.
三维（3D）打印技术在各个领域的应用正在不断扩大。在美国食品和药物管理局（FDA）批准 3D 打印片剂后，预计 3D 打印在制药行业的应用将会增加。熔融沉积成型（FDM）是 3D 打印的一种类型，已经广泛研究用于制造片剂。可以使用热熔挤出法或简单的药物浸泡法制备载药聚合物长丝，即 FDM 3D 打印机的墨水。在本研究中，我们通过浸泡法研究了实验条件对姜黄素（带荧光的模型药物）载入聚乙烯醇聚合物长丝的影响。结果表明，有机溶剂类型（异丙醇、甲醇、丙酮和乙醇）、温度（25 和 80°C）和药物浓度（2-333mg/mL）对载药量有很大影响。使用浸泡法可以将约 5%的姜黄素掺入聚乙烯醇长丝中。3D 打印片剂的药物溶出取决于聚合物长丝中的药物含量。掺入更高量的水溶性差的姜黄素会大大延迟药物溶出。这些结果为使用浸泡法制备载药聚合物长丝的 3D 打印片剂提供了有用的信息。
