Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Comp Immunol Microbiol Infect Dis. 2019 Dec;67:101354. doi: 10.1016/j.cimid.2019.101354. Epub 2019 Sep 26.
Microevolutionary data of Strongyloides stercoralis infrapopulations are regarded as a requirement for determining the global genetic structure and transmission paradigms of this neglected tropical nematode among the neighboring countries of the world. English databases were searched from 2010 to 2019, analyzing a total of 10 publications. The cytochrome c oxidase subunit 1 sequences of S. stercoralis isolated from Asian and African continents were subjected to calculate the diversity indices and genetic differentiation. A parsimonious haplotype network indicated a star-like trait a total of 106 (Homo sapiens) and 48 haplotypes (Canid) being grouped into four distinct geographical haplogroups. A significant genetic diversity was identified in human-derived S. stercoralis (Haplotype diversity: 0.78) and those with dog (Hd: 0.86) origins. Cladistic phylogenetic tree indicated the Japanese, Thailandish, and Myanmarese clades have a sister relationship with the Laotian clade. The statistically significant Fst values indicated that human S. stercoralis populations of Japanese-Thailandish, Japanese-Myanmarese, and Japanese-Laotian origins were genetically differentiated (Fst: 0.48430 to 0.54903). We conclude that a high gene migration of human strongyloidiasis is being unequivocally shared between the Laotion-Myanmarese and Laotion-Thailandish population pairs. The current findings enhance our knowledge to assess the transmission dynamics and the evolutionary patterns of S. stercoralis in various geographical regions of the globe; also it will serve as a basis for public health policy to control human strongyloidiasis particularly in immunocompromised individuals. Besides, the infected canids and other environmental reservoirs for zoonotic transmission of S. stercoralis to humans should be de-wormed along with their owners.
弱茎槽属 infrapopulations 的微进化数据被认为是确定这种被忽视的热带线虫在世界邻国中的全球遗传结构和传播模式的要求。从 2010 年到 2019 年，对英文数据库进行了搜索，共分析了 10 篇出版物。对来自亚洲和非洲大陆的弱茎槽属分离株的细胞色素 c 氧化酶亚基 1 序列进行了计算，以计算多样性指数和遗传分化。简约单倍型网络表明，总共 106 个（智人）和 48 个单倍型（犬科动物）分为四个不同的地理单倍型群。人类来源的弱茎槽属（单倍型多样性：0.78）和犬科动物来源的弱茎槽属（Hd：0.86）具有显著的遗传多样性。分支系统发生树表明，日本、泰国和缅甸支系与老挝支系具有姐妹关系。统计上显著的 Fst 值表明，来自日本-泰国、日本-缅甸和日本-老挝的人类弱茎槽属种群在遗传上存在分化（Fst：0.48430 至 0.54903）。我们得出结论，人类粪类圆线虫的高基因迁移在老挝-缅甸和老挝-泰国人群中被明确共享。目前的研究结果增强了我们对评估粪类圆线虫在全球不同地理区域传播动态和进化模式的认识；也为控制人类粪类圆线虫病特别是免疫功能低下个体的公共卫生政策提供了依据。此外，应该对受感染的犬科动物和其他环境储层进行驱虫，以防止粪类圆线虫向人类传播。
