Department of Biological Production, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Neopharma Japan, Tokyo 102-0071, Japan.
J Dairy Sci. 2019 Dec;102(12):11009-11015. doi: 10.3168/jds.2018-15982. Epub 2019 Oct 3.
The objective of this study was to investigate the effect of 5-aminolevulinic acid (5-ALA) as a dietary supplement on milk yield and composition as well as iron status and immune response in lactating dairy cows. In this study 13 lactating Holstein cows were randomly assigned to either a control group or a treatment group supplemented with 10 mg of 5-ALA per kilogram of dry matter. During feeding, 5-ALA was mixed with a small amount of the total mixed ration and top-dressed. The experiments followed a crossover design with 2 periods. Each period consisted of an adaptation period of 12 d and a test period of 2 d. Dairy cows fed the diet supplemented with 5-ALA exhibited increased counts of white blood cells and granulocytes compared with the control group. The rate of phagocytosis and mitogen-induced proliferation of peripheral blood mononuclear cells in cows fed 5-ALA were higher than in cows fed a basal diet. However, 5-ALA did not affect iron status or plasma biochemical composition. Supplementation with 5-ALA improved milk protein and milk casein contents; however, it had no effect on milk production, milk fat, lactose, total solids, or solids-not-fat, compared with the control. We conclude that dietary supplementation of 5-ALA to lactating dairy cows may have a positive effect on milk protein synthesis and the immune response.
本研究旨在探讨 5-氨基乙酰丙酸（5-ALA）作为膳食补充剂对泌乳奶牛产奶量、组成以及铁状态和免疫反应的影响。在这项研究中，将 13 头泌乳荷斯坦奶牛随机分为对照组或治疗组，后者每千克干物质补充 10 毫克 5-ALA。在喂养过程中，将 5-ALA 与少量总混合日粮混合，并撒上。该实验采用交叉设计，分为 2 个时期。每个时期包括 12 天的适应期和 2 天的测试期。与对照组相比，饲喂添加 5-ALA 的日粮的奶牛白细胞和粒细胞计数增加。饲喂 5-ALA 的奶牛外周血单核细胞的吞噬率和有丝分裂原诱导增殖率高于饲喂基础日粮的奶牛。然而，5-ALA 并未影响铁状态或血浆生化成分。与对照组相比，补充 5-ALA 可提高牛奶蛋白和牛奶酪蛋白含量；然而，与对照组相比，它对产奶量、乳脂、乳糖、总固体或非脂固体没有影响。我们得出结论，向泌乳奶牛日粮中添加 5-ALA 可能对牛奶蛋白合成和免疫反应有积极影响。
