Iordache Cristina, Antohe Magda-Ecaterina, Chirieac Rodica, Ancuța Eugen, Țănculescu Oana, Ancuța Codrina
Grigore T. Popa University of Medicine and Pharmacy, School of Dental Medicine, Department of Implantology, Removable Dentures, Technology, Iasi 700115, Romania.
SANCARE Medical and Research Center, Iasi 700503, Romania.
J Clin Med. 2019 Oct 4;8(10):1620. doi: 10.3390/jcm8101620.
Background Oral health issues are commonly reported in systemic sclerosis (SSc), comprising a broad spectrum of manifestations, e.g., reduced mouth opening, periodontal disease, increased periodontal ligament (PDL) space width, and mandibular resorption. We aimed to assess oral radiographic abnormalities, particularly PDL space widening and erosions, and to identify potential relations with disease measures. Methodsross-sectional study in 43 SSc and matching controls receiving systematic oral assessments (full mouth dental/periodontal) and imaging (radiographs and cone beam computed tomography (CBCT)). Associations between disease variables and radiologic findings were investigated by univariate and multivariate analysis (SPSS-v.20, < 0.05). Results CBCT demonstrated generalized PDL space widening in up to half SSc, with at least one tooth involved, essentially in the posterior region (p < 0.05). Significant correlations between number of teeth with PDL space widening and disease severity, skin score, disease subset, topoisomerase I specificity, age, and disease duration were reported (p < 0.05). Additionally, mandibular erosions were described in one out of four patients, commonly condylar erosions. Conclusions: Tridimensional CBCT approach confirmed widening of PDL and mandibular erosions as common dental findings in scleroderma. Furthermore, widened PDL spaces correlated with several disease characteristics including severity, skin extent, and antibody profile.
系统性硬化症（SSc）中常报告有口腔健康问题，表现形式多样，例如张口受限、牙周病、牙周膜（PDL）间隙增宽和下颌骨吸收。我们旨在评估口腔影像学异常，尤其是PDL间隙增宽和骨质侵蚀，并确定其与疾病指标之间的潜在关系。方法：对43例SSc患者及匹配的对照组进行横断面研究，接受系统的口腔评估（全口牙齿/牙周检查）和影像学检查（X线片和锥形束计算机断层扫描（CBCT））。通过单因素和多因素分析（SPSS v.20，<0.05）研究疾病变量与影像学结果之间的关联。结果：CBCT显示，高达半数的SSc患者存在广泛性PDL间隙增宽，至少累及一颗牙齿，主要位于后部区域（p<0.05）。报告显示，PDL间隙增宽的牙齿数量与疾病严重程度、皮肤评分、疾病亚型、拓扑异构酶I特异性、年龄和病程之间存在显著相关性（p<0.05）。此外，四分之一的患者出现下颌骨侵蚀，常见为髁突侵蚀。结论：三维CBCT方法证实，PDL增宽和下颌骨侵蚀是硬皮病常见的牙科表现。此外，增宽的PDL间隙与包括严重程度、皮肤范围和抗体谱在内的多种疾病特征相关。
