Arefkhah Nasir, Vafazadeh Sina, Shahriarirad Sepehr, Ghorbani Fariba, Zoghi Sina, Emami Mehdi, Zamiri Bardia, Cheraghi Mohammad Reza, Sarvari Jamal, Sarkari Bahador
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Immunoassay Immunochem. 2020;41(1):20-27. doi: 10.1080/15321819.2019.1675696. Epub 2019 Oct 7.
The present study aimed to find out the levels of anti-HBsAb among vaccinated children in a rural community in Fars Province, Southern Iran. Blood samples were taken from 550 children, aged 1-12 years (mean 6.4 ± 3.5), in 2017 from three villages in the area. A structured questionnaire was used to get the sociodemographic data of the subjects along with determinants concerning the Hepatitis B. Sera samples were examined for anti-HBsAb, using an ELISA commercial kit. Anti-HBsAb were detected in 468 (85.1%) of the subjects. Of the seropositive subjects, 37 (45.1%) were female and 45 (54.9%) were male. In the age group of 0-5 years, 88.7% of the subjects were seropositive. This rate was 84.3% and 78.1% in the age group of 6-10 years old and older than 10 years, respectively. There was a significant association ( < .05) between the anti-HBsAb and age. Findings of the current study revealed that children living in a rural community in southern Iran have appropriate protection against HBV even more than 10 years after being vaccinated. The decline in seropositivity rate of anti-HBsAb with age may further point out the need for a booster dose of HBV vaccine.
本研究旨在了解伊朗南部法尔斯省一个农村社区接种疫苗儿童的抗-HBsAb水平。2017年从该地区三个村庄的550名1至12岁（平均6.4±3.5岁）儿童中采集血样。使用结构化问卷获取受试者的社会人口统计学数据以及与乙型肝炎相关的决定因素。使用ELISA商用试剂盒检测血清样本中的抗-HBsAb。468名（85.1%）受试者检测到抗-HBsAb。在血清阳性受试者中，37名（45.1%）为女性，45名（54.9%）为男性。在0至5岁年龄组中，88.7%的受试者血清呈阳性。在6至10岁和10岁以上年龄组中，这一比例分别为84.3%和78.1%。抗-HBsAb与年龄之间存在显著关联（<0.05）。本研究结果显示，伊朗南部农村社区的儿童在接种疫苗十多年后对乙肝病毒仍有适当的保护。抗-HBsAb血清阳性率随年龄下降可能进一步表明需要接种一剂乙肝疫苗加强针。
