Ristikj-Stomnaroska Daniela, Risteska-Nejashmikj Valentina, Papazova Marija
Department of Neurology, City General Hospital 8th September, Skopje, Republic of Macedonia.
Center for Family Medicine, Faculty of Medicine, Skopje, Republic of Macedonia.
Open Access Maced J Med Sci. 2019 Jul 25;7(14):2267-2270. doi: 10.3889/oamjms.2019.646. eCollection 2019 Jul 30.
Diabetic peripheral neuropathy (DPN) means the presence of symptoms and/or signs of peripheral nerve damage that occur to people with diabetes, excluding all other causes of neuropathy. Chronic hyperglycaemia leads to increased secretion of tumour necrotic factor-alpha (TNF-α), with the development of micro and macroangiopathy, damage to nerve fibres and local demyelination.
To determine the role of inflammation in the peripheral nerve damage process concerning people suffering from type II diabetes mellitus.
The study included a total of 80 subjects, men and women, divided into two groups: an examined group (n = 50) consisting of subjects with DPN at the age from 30 to 80 years and a control group (n = 30) of healthy subjects aged from 18 to 45. In the investigated group, a neurological examination was performed using the Diabetic Neuropathy Symptoms (DNS) Score and Electroneurography. All the subjects had the blood plasma concentration of TNF-α by ELISA technique.
The average value of TNF-α in the test group was 8.24 ± 2.899 pg/ml, while the control group was 4.36 ± 2.622 pg/ml (p < 0.0001). The average value of TNF-α was correlated with the achieved DNS score in the investigated group (p = 0.005). Concerning the linear association of the concentration of TNF-α with the peripheral nerve velocity in the investigated group, no statistical significance was detected.
Inflammation can play a role in the pathogenesis of diabetic autonomic neuropathy and cranial neuritis.
糖尿病性周围神经病变（DPN）是指糖尿病患者出现周围神经损伤的症状和/或体征，排除所有其他神经病变原因。慢性高血糖导致肿瘤坏死因子-α（TNF-α）分泌增加，伴有微血管和大血管病变的发展、神经纤维损伤和局部脱髓鞘。
确定炎症在2型糖尿病患者周围神经损伤过程中的作用。
该研究共纳入80名受试者，包括男性和女性，分为两组：实验组（n = 50），由年龄在30至80岁的DPN患者组成；对照组（n = 30），由年龄在18至45岁的健康受试者组成。在实验组中，使用糖尿病神经病变症状（DNS）评分和神经电生理检查进行神经学检查。所有受试者均采用酶联免疫吸附测定（ELISA）技术检测血浆TNF-α浓度。
测试组中TNF-α的平均值为8.24±2.899 pg/ml，而对照组为4.36±2.622 pg/ml（p < 0.0001）。实验组中TNF-α的平均值与所获得的DNS评分相关（p = 0.005）。关于实验组中TNF-α浓度与周围神经速度的线性关联，未检测到统计学意义。
炎症可能在糖尿病性自主神经病变和颅神经炎的发病机制中起作用。
