School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.
Chemistry. 2020 Jan 7;26(2):374-378. doi: 10.1002/chem.201904479. Epub 2019 Nov 7.
The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. The first electrochemical functionalisation of cubane by oxidative decarboxylative ether formation (Hofer-Moest reaction) was demonstrated. The mild conditions are compatible with the presence of other oxidisable functional groups, and the use of flow electrochemical conditions allows straightforward upscaling.
高度应变的立方烷系统作为药物和材料化学中的支架和刚性连接体具有很大的研究兴趣。首次通过氧化脱羧基醚形成（Hofer-Moest 反应）实现了立方烷的电化学功能化。温和的条件与其他可氧化官能团的存在兼容，并且使用流动电化学条件允许直接放大。
