Brown G L, Richardson J D, Malangoni M A, Tobin G R, Ackerman D, Polk H C
Ann Surg. 1985 Jun;201(6):705-11. doi: 10.1097/00000658-198506000-00006.
Abdominal wall defects resulting from trauma, invasive infection, or hernia present a difficult problem for the surgeon. In order to study the problems associated with the prosthetic materials used for abdominal wall reconstruction, an animal model was used to simulate abdominal wall defects in the presence of peritonitis and invasive infection. One hundred guinea pigs were repaired with either polytetrafluorethylene (PTFE) or polypropylene mesh (PPM). Our experiments included intra-operative contamination with Staphylococcus aureus. We found significantly fewer organisms (p less than 0.05) adherent to the PTFE than to the PPM when antibiotics were administered after surgery, as well as when no antibiotics were given. In the presence of peritonitis, we found no real difference in numbers of intraperitoneal bacteria present whether PTFE or PPM was used. In all instances, the PTFE patches produced fewer adhesions and were more easily removed. From these experiments, it appears that PTFE may be associated with fewer problems than PPM in the presence of contamination and infection.
由创伤、侵袭性感染或疝气导致的腹壁缺损给外科医生带来了难题。为了研究与用于腹壁重建的修复材料相关的问题，采用动物模型来模拟存在腹膜炎和侵袭性感染时的腹壁缺损。100只豚鼠分别用聚四氟乙烯（PTFE）或聚丙烯网片（PPM）进行修复。我们的实验包括术中用金黄色葡萄球菌污染。我们发现，术后使用抗生素以及未使用抗生素时，附着在PTFE上的微生物数量均显著少于附着在PPM上的微生物数量（p小于0.05）。在存在腹膜炎的情况下，无论使用PTFE还是PPM，我们发现腹腔内细菌数量并无实际差异。在所有情况下，PTFE补片产生的粘连较少且更容易移除。从这些实验来看，在存在污染和感染的情况下，PTFE可能比PPM出现的问题更少。
