Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Mol Pharm. 2022 Apr 4;19(4):1033-1046. doi: 10.1021/acs.molpharmaceut.1c00960. Epub 2022 Mar 11.
Ionic liquids (ILs) are a class of nonmolecular compounds composed only of ions. Compared with traditional organic solvents, ILs have the advantages of wide chemical space, diverse and flexible structures, negligible vapor pressure, and high thermal stability, which make them widely used in many fields of modern science, such as chemical synthesis and catalytic decomposition, electrochemistry, biomass conversion, and biotransformation biotechnology. Because of their special characteristics, ILs have been favored in the pharmaceutical field recently, especially for the development of efficient drug delivery systems. So far, ILs have been successfully designed to promote the dissolution of poorly soluble drugs and the destruction of physiological barriers, such as the tight junction between the stratum corneum and the intestinal epithelium. In addition, ILs can also be combined with other drug strategies to stabilize the structure of small molecules. This Review mainly introduces the application of ILs in drug delivery, emphasizes the potential mechanism of ILs, and presents the key research directions of ILs in the future.
离子液体（ILs）是仅由离子组成的一类非分子化合物。与传统有机溶剂相比，ILs 具有广阔的化学空间、多样且灵活的结构、可忽略的蒸气压和高的热稳定性，这使得它们在现代科学的许多领域得到了广泛应用，如化学合成和催化分解、电化学、生物质转化和生物转化生物技术。由于其特殊的特性，ILs 最近在制药领域受到青睐，特别是在开发高效药物传递系统方面。到目前为止，已经成功设计了 ILs 来促进难溶性药物的溶解和生理屏障的破坏，如角质层和肠上皮细胞之间的紧密连接。此外，ILs 还可以与其他药物策略结合使用，以稳定小分子的结构。这篇综述主要介绍了 ILs 在药物传递中的应用，强调了 ILs 的潜在机制，并提出了 ILs 在未来的关键研究方向。
