Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
The Third Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu, China.
J Cell Physiol. 2020 Mar;235(3):2273-2285. doi: 10.1002/jcp.29135. Epub 2019 Oct 8.
An in-depth understanding of circular RNAs (circRNAs) indicates that they are abundant in the eukaryotic transcriptome. Many circRNAs act as microRNA sponges; thus, they represent a new type of regulatory factor. However, the role of circRNA in colorectal cancer (CRC) remains largely unknown. Low circ_0021977 expression in patients with CRC is associated with higher tug-lymph node metastasis (TNM) stage and poorer prognosis compared with patients with high circ_0021977 expression. Moreover, miR-10b-5p was shown to be a target of circ_0021977, and p21 and p53 are suggested to be putative target genes of miR-10b-5p. The results showed that the circ_0021977/miR-10b-5p/p21&p53 regulatory axis suppresses proliferation, migration, and invasion by CRC cells. This evidence reveals new relationships and brings new highlights to the treatment of CRC.
深入了解环状 RNA（circRNAs）表明，它们在真核转录组中大量存在。许多 circRNAs 作为 microRNA 海绵起作用；因此，它们代表了一种新型的调节因子。然而，circRNA 在结直肠癌（CRC）中的作用在很大程度上仍然未知。与高 circ_0021977 表达的患者相比，CRC 患者中 circ_0021977 的低表达与更高的 tug-lymph node metastasis（TNM）分期和更差的预后相关。此外，circ_0021977 被证明是 miR-10b-5p 的靶标，p21 和 p53 被认为是 miR-10b-5p 的潜在靶基因。结果表明，circ_0021977/miR-10b-5p/p21&p53 调节轴通过抑制 CRC 细胞的增殖、迁移和侵袭来发挥作用。这一证据揭示了新的关系，并为 CRC 的治疗带来了新的亮点。
