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1
T cells recognize minor histocompatibility antigens on H-2 allogeneic cells.T细胞识别H-2同种异体细胞上的次要组织相容性抗原。
J Exp Med. 1979 Oct 1;150(4):1001-7. doi: 10.1084/jem.150.4.1001.
2
Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells.抗原在T细胞上不适当呈递时对细胞毒性T细胞诱导的单倍型特异性抑制。
J Exp Med. 1983 Jan 1;157(1):141-54. doi: 10.1084/jem.157.1.141.
3
Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming.在体内致敏过程中，引入到H-2不同刺激细胞上的次要H抗原在细胞毒性T细胞水平发生交叉反应。
J Immunol. 1976 Dec;117(6):2233-8.
4
Cytotoxic T cell response to minor histocompatibility antigens: apparent lack of H-2 restriction in killers stimulated by membrane fragments.细胞毒性T细胞对次要组织相容性抗原的反应：膜片段刺激的杀伤细胞中明显缺乏H-2限制。
J Exp Med. 1982 Jul 1;156(1):217-29. doi: 10.1084/jem.156.1.217.
5
Selection of cytotoxic T-cell precursors specific for minor histocompatibility determinants. I. Negative selection across H-2 barriers induced with disrupted cells but not with glutaraldehyde-treated cells: evidence for antigen processing.针对次要组织相容性决定簇的细胞毒性T细胞前体的选择。I. 用破碎细胞而非戊二醛处理的细胞诱导跨越H-2屏障的阴性选择：抗原加工的证据。
J Exp Med. 1980 Feb 1;151(2):314-27. doi: 10.1084/jem.151.2.314.
6
Cytotoxic T-lymphocyte tolerance to minor H-43a alloantigen is induced exclusively in the context of the self major histocompatibility complex class I H-2Kb molecules.
Cell Immunol. 1987 Dec;110(2):436-42. doi: 10.1016/0008-8749(87)90136-5.
7
Abrogation of hybrid resistance to bone marrow engraftment by graft-vs-host-induced immune deficiency.移植物抗宿主诱导的免疫缺陷消除了对骨髓移植的混合抗性。
J Immunol. 1986 Nov 15;137(10):3109-16.
8
Tolerance to minor histocompatibility antigens.对次要组织相容性抗原的耐受性。
Immunol Lett. 1988 Mar;17(3):253-9. doi: 10.1016/0165-2478(88)90038-7.
9
Characterization of cytotoxic cells in mice rendered neonatally tolerant of MHC alloantigens: evidence for repertoire modification.新生期对MHC同种异体抗原耐受的小鼠中细胞毒性细胞的特征：免疫库修饰的证据
J Immunol. 1987 Jun 1;138(11):3661-8.
10
Cytotoxic T lymphocyte response to minor H-42a alloantigen in H-42b mice: clonal inactivation of the precursor cytotoxic T lymphocytes by veto-like spleen cells that express the H-42a antigen.H-42b小鼠对次要H-42a同种抗原的细胞毒性T淋巴细胞反应：表达H-42a抗原的类否决脾细胞对细胞毒性T淋巴细胞前体的克隆失活。
J Immunol. 1986 Oct 1;137(7):2080-8.

引用本文的文献

1
Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus.在B6小鼠中诱导对H-2k的新生期耐受性并不能使针对H-2k加痘苗病毒的T细胞出现。
J Exp Med. 1982 Sep 1;156(3):810-21. doi: 10.1084/jem.156.3.810.
2
Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.克隆化细胞毒性T淋巴细胞的抗原识别遵循改变自身假说所预测的规则。
J Exp Med. 1982 Jan 1;155(1):111-25. doi: 10.1084/jem.155.1.111.
3
H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.作为有意致敏结果的H-2限制。正常小鼠胸腺细胞内同种抗原限制的、三硝基苯基特异性细胞毒性T淋巴细胞前体的频率分析。
J Exp Med. 1981 Jun 1;153(6):1629-39. doi: 10.1084/jem.153.6.1629.
4
T cell recognition of antigen in vivo: role of the H-2 complex.体内T细胞对抗原的识别：H-2复合体的作用。
Springer Semin Immunopathol. 1980 Aug;3(2):213-45. doi: 10.1007/BF02053976.
5
Cytotoxic T lymphocyte nonresponsiveness to the male antigen H-Y in the H-2Db mutants bm13 and bm14. Complementation of the response in F1 crosses with the I-Ab mutant bm12 nonresponder and failure of B6 or Db mutant mice tolerant of each other to respond to allogeneic male cells.细胞毒性T淋巴细胞对H-2Db突变体bm13和bm14中雄性抗原H-Y无反应性。与I-Ab突变体bm12无反应者进行F1杂交时反应的互补，以及相互耐受的B6或Db突变体小鼠对同种异体雄性细胞无反应。
J Exp Med. 1983 Nov 1;158(5):1537-46. doi: 10.1084/jem.158.5.1537.
6
Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.半抗原可以作为替代移植抗原，其方式显示出移植物排斥反应的H-2限制性。
J Exp Med. 1983 Apr 1;157(4):1354-9. doi: 10.1084/jem.157.4.1354.
7
H-2L-restricted recognition of viral antigens In the H-2d haplotype, anti-vesicular stomatitis virus cytotoxic T cells are restricted solely by H-2L.H-2L对病毒抗原的限制性识别 在H-2d单倍型中，抗水泡性口炎病毒细胞毒性T细胞仅受H-2L的限制。
J Exp Med. 1982 Sep 1;156(3):778-90. doi: 10.1084/jem.156.3.778.
8
H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.因有意致敏而导致的H-2限制：完全异基因嵌合小鼠以及正常小鼠的T细胞在胸腺上皮细胞上未遇到的H-2决定簇的背景下对外源抗原产生反应。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7390-4. doi: 10.1073/pnas.77.12.7390.
9
Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells.抗原在T细胞上不适当呈递时对细胞毒性T细胞诱导的单倍型特异性抑制。
J Exp Med. 1983 Jan 1;157(1):141-54. doi: 10.1084/jem.157.1.141.
10
Cytotoxic T cell response to minor histocompatibility antigens: apparent lack of H-2 restriction in killers stimulated by membrane fragments.细胞毒性T细胞对次要组织相容性抗原的反应：膜片段刺激的杀伤细胞中明显缺乏H-2限制。
J Exp Med. 1982 Jul 1;156(1):217-29. doi: 10.1084/jem.156.1.217.

本文引用的文献

1
Spleen cell proliferation in response to homologous antigens studied in congenic resistant strains of mice.在同基因抗性小鼠品系中研究的对同源抗原作出反应的脾细胞增殖。
J Exp Med. 1966 Apr 1;123(4):665-71. doi: 10.1084/jem.123.4.665.
2
Neonatal tolerance induction across regions of H-2 complex.
J Immunol. 1977 Dec;119(6):2147-50.
3
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
J Exp Med. 1978 Mar 1;147(3):882-96. doi: 10.1084/jem.147.3.882.
4
Cytotoxic t-cell response to histocompatibility antigens: the role of H-2.细胞毒性T细胞对组织相容性抗原的反应：H-2的作用。
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:519-27. doi: 10.1101/sqb.1977.041.01.060.
5
Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.半同种异体嵌合体中的原发性抗病毒细胞毒性T细胞反应并非绝对局限于宿主H-2类型。
J Exp Med. 1979 Feb 1;149(2):535-8. doi: 10.1084/jem.149.2.535.
6
Estimates of the precursor frequency of cytotoxic T lymhocytes against antigens controlled by defined regions of the H-2 gene complex: comparison of the effect of H-2 differences due to intra-H-2 recombination vs mutation.针对由H-2基因复合体特定区域控制的抗原的细胞毒性T淋巴细胞前体频率的估计：H-2基因复合体内重组与突变导致的H-2差异效应的比较
J Immunol. 1978 Oct;121(4):1302-5.
7
In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.在完全H-2不相容的嵌合体中，供体来源的T细胞可对与供体或宿主H-2类型相关的次要组织相容性抗原产生反应。
J Exp Med. 1978 Jul 1;148(1):84-92. doi: 10.1084/jem.148.1.84.

T细胞识别H-2同种异体细胞上的次要组织相容性抗原。

T cells recognize minor histocompatibility antigens on H-2 allogeneic cells.

作者信息

Forman J, Streilein J W

出版信息

J Exp Med. 1979 Oct 1;150(4):1001-7. doi: 10.1084/jem.150.4.1001.

DOI:10.1084/jem.150.4.1001
PMID:315984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185680/
Abstract

B10.A animals were rendered tolerant to B10.M spleen cells by injection of (B10.A X B10.M)F1 cells into neonates. Adult animals accepted B10.M skin grafts and failed to generate cytotoxic effector cells in vitro against B10.M H-2 antigens. In vivo inoculation of tolerant animals with A.CA spleen cells, followed by in vitro challenge with similar cells, resulted in the generation of cytotoxic effector cells that had specificity for the A strain minor histocompatibility (H)-antigens in the context of the H-2f haplotype. If these animals were boosted in vitro with A strain spleen cells, cross-priming could be demonstrated, whereby the cytotoxic effect was restricted by the H-2a haplotype. These data indicate that at least two sets of T cells co-exist in tolerant animals, one capable of recognizing antigens in the context of the host H-2 haplotype, and the other able to recognize antigens in the context of the tolerated H-2-allogeneic haplotype. Because tolerant animals inoculated with A-strain spleen cells in vivo and boosted in vitro with A.CA spleen cells failed to generate a cytotoxic effect against A.CA, it is unlikely that minor H-antigens need to be processed by host lymphoreticular cells.

摘要

通过向新生B10.A动物注射（B10.A×B10.M）F1细胞，使其对B10.M脾细胞产生耐受性。成年动物接受了B10.M皮肤移植，并且在体外未能产生针对B10.M H-2抗原的细胞毒性效应细胞。用A.CA脾细胞对耐受性动物进行体内接种，随后用相似细胞进行体外攻击，导致产生了对H-2f单倍型背景下A品系次要组织相容性（H）抗原具有特异性的细胞毒性效应细胞。如果用A品系脾细胞在体外增强这些动物的免疫反应，就可以证明交叉致敏的存在，由此细胞毒性效应受H-2a单倍型限制。这些数据表明，在耐受性动物中至少存在两组T细胞，一组能够在宿主H-2单倍型背景下识别抗原，另一组能够在耐受的H-2同种异体单倍型背景下识别抗原。由于在体内接种A品系脾细胞并用A.CA脾细胞在体外增强免疫反应的耐受性动物未能产生针对A.CA的细胞毒性效应，因此次要H抗原不太可能需要宿主淋巴网状细胞进行处理。