半抗原可以作为替代移植抗原，其方式显示出移植物排斥反应的H-2限制性。
Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.
作者信息
Streilein J W, Bergstresser P R
出版信息
J Exp Med. 1983 Apr 1;157(4):1354-9. doi: 10.1084/jem.157.4.1354.
Abstract
Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derivatized with the relevant hapten, but only if the hapten is applied while the graft is "healing in." This model system was used to demonstrate that the hapten-specific immune effectors responsible for rejection are restricted by H-2 determinants of the recipient. Thus, haptens can be used in vivo as surrogate transplantation antigens for the study of immunopathogenic mechanisms in transplantation immunity.
摘要
半抗原免疫的小鼠能够排斥用相关半抗原衍生化的同基因皮肤移植物，但前提是在移植物“愈合”时应用半抗原。该模型系统被用于证明负责排斥反应的半抗原特异性免疫效应细胞受受体的H-2决定簇限制。因此，半抗原在体内可作为替代移植抗原，用于研究移植免疫中的免疫致病机制。
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Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.半抗原可以作为替代移植抗原，其方式显示出移植物排斥反应的H-2限制性。
J Exp Med. 1983 Apr 1;157(4):1354-9. doi: 10.1084/jem.157.4.1354.
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The induction of tolerance to DNFB contact sensitivity using hapten modified lymphoid cells. I. Cellular requirements for rapid induction of tolerance.使用半抗原修饰的淋巴细胞诱导对二硝基氟苯接触敏感性的耐受性。I. 快速诱导耐受性的细胞要求。
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Genetic restrictions for the induction of suppressor T cells by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity. Role of the H-2D region of the major histocompatibility complex.在对1-氟-2,4-二硝基苯接触敏感性的耐受性中，半抗原修饰的淋巴细胞诱导抑制性T细胞的遗传限制。主要组织相容性复合体H-2D区域的作用。
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Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants.对半抗原同基因和半抗原异基因决定簇具有活性的接触敏感性耐受中的抑制细胞。
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Desensitization of contact allergy to DNFB in mice. III. Characteristics of immediate desensitization induced by haptenated spleen cells.小鼠对二硝基氟苯接触性过敏的脱敏作用。III. 半抗原化脾细胞诱导的即刻脱敏作用的特征
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引用本文的文献
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Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo.克隆化的LYT-2+细胞毒性T淋巴细胞在体内可破坏同种异体组织。
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本文引用的文献
1
Evidence for major histocompatibility complex restriction in transplantation immunity.移植免疫中主要组织相容性复合体限制的证据。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):171-4. doi: 10.1073/pnas.79.1.171.
2
The vascular bed as the primary target in the destruction of skin grafts by antiserum. I. Resistance of freshly placed xenografts of skin to antiserum.血管床作为抗血清破坏皮肤移植的主要靶点。I. 新鲜植入的异种皮肤移植对抗血清的抵抗力。
J Exp Med. 1981 Nov 1;154(5):1319-31. doi: 10.1084/jem.154.5.1319.
3
H-2 restriction of T cells causing lethal graft-versus-host disease across minor histocompatibility barriers in mice.小鼠中跨越次要组织相容性屏障导致致死性移植物抗宿主病的T细胞的H-2限制性
Transplant Proc. 1981 Mar;13(1 Pt 2):1217-9.
4
Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.介导小鼠移植物排斥反应的细胞。I. Lyt-1细胞介导皮肤移植物排斥反应。
J Exp Med. 1981 May 1;153(5):1044-57. doi: 10.1084/jem.153.5.1044.
5
Maturation of cytotoxic effector cells at the site of allograft rejection.同种异体移植排斥反应部位细胞毒性效应细胞的成熟。
Transplant Proc. 1981 Mar;13(1 Pt 2):1105-7.
6
7
The vascular bed as the primary target in the destruction of skin grafts by antiserum. II. Loss of sensitivity to antiserum in long-term xenografts of skin.血管床作为抗血清破坏皮肤移植的主要靶点。II. 皮肤长期异种移植中对抗血清敏感性的丧失。
J Exp Med. 1981 Nov 1;154(5):1332-41. doi: 10.1084/jem.154.5.1332.
8
Active clonal deletion in neonatal H-2 tolerance.新生期H-2耐受中的活性克隆清除
Ann N Y Acad Sci. 1982;392:276-90. doi: 10.1111/j.1749-6632.1982.tb36113.x.
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Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses.细胞介导的免疫：迟发型超敏反应和细胞毒性反应由不同的T细胞亚类介导。
J Exp Med. 1976 Jun 1;143(6):1534-9. doi: 10.1084/jem.143.6.1534.
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