Streilein J W, Bergstresser P R
J Exp Med. 1983 Apr 1;157(4):1354-9. doi: 10.1084/jem.157.4.1354.
Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derivatized with the relevant hapten, but only if the hapten is applied while the graft is "healing in." This model system was used to demonstrate that the hapten-specific immune effectors responsible for rejection are restricted by H-2 determinants of the recipient. Thus, haptens can be used in vivo as surrogate transplantation antigens for the study of immunopathogenic mechanisms in transplantation immunity.
半抗原免疫的小鼠能够排斥用相关半抗原衍生化的同基因皮肤移植物,但前提是在移植物“愈合”时应用半抗原。该模型系统被用于证明负责排斥反应的半抗原特异性免疫效应细胞受受体的H-2决定簇限制。因此,半抗原在体内可作为替代移植抗原,用于研究移植免疫中的免疫致病机制。