Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
Cancer Sci. 2019 Dec;110(12):3630-3638. doi: 10.1111/cas.14211. Epub 2019 Oct 25.
Circular RNAs (circRNAs) have a covalently closed circular conformation and are structurally stable. Those circRNAs with tumor-suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Herein, we review the current understanding of the classification of circRNAs and summarize the functions and mechanisms of circRNAs that have tumor-suppressive roles in various cancers, including liver cancer (circARSP91, circADAMTS13, circADAMTS14, circMTO1, hsa_circ_0079299, and circC3P1), bladder cancer (circFNDC3B, circITCH, circHIPK3, circRNA-3, cdrlas, and circLPAR1), gastric cancer (circLARP4, circYAP1, hsa_cric_0000096, hsa_circ_0000993, and circPSMC3), breast cancer (circ_000911, hsa_circ_0072309, and circASS1), lung cancer (hsa_circ_0000977, circPTK2, circ_0001649, hsa_circ_100395, and circ_0006916), glioma (circ_0001946, circSHPRH, and circFBXW7), and colorectal cancer (circITGA7 and hsa_circ_0014717). Thanks to their structural stability, these tumor-suppressive circRNAs may be used as potential and potent therapeutic targets. Moreover, we propose a new method for the classification of circRNAs. Based on whether they can be translated, circRNAs can be divided into noncoding circRNAs and coding circRNAs.
环状 RNA（circRNAs）具有共价闭合的环状结构，结构稳定。那些具有肿瘤抑制特性的 circRNAs 在肿瘤发生和转移中发挥重要作用，因此可能成为癌症的治疗靶点。本文综述了 circRNAs 的分类，并总结了在各种癌症中具有肿瘤抑制作用的 circRNAs 的功能和机制，包括肝癌（circARSP91、circADAMTS13、circADAMTS14、circMTO1、hsa_circ_0079299 和 circC3P1）、膀胱癌（circFNDC3B、circITCH、circHIPK3、circRNA-3、cdrlas 和 circLPAR1）、胃癌（circLARP4、circYAP1、hsa_cric_0000096、hsa_circ_0000993 和 circPSMC3）、乳腺癌（circ_000911、hsa_circ_0072309 和 circASS1）、肺癌（hsa_circ_0000977、circPTK2、circ_0001649、hsa_circ_100395 和 circ_0006916）、神经胶质瘤（circ_0001946、circSHPRH 和 circFBXW7）和结直肠癌（circITGA7 和 hsa_circ_0014717）。由于其结构稳定性，这些肿瘤抑制性 circRNAs 可能成为潜在的有效治疗靶点。此外，我们提出了一种新的 circRNAs 分类方法。根据是否可以翻译，circRNAs 可分为非编码 circRNAs 和编码 circRNAs。
