Xi Jiancheng, Luo Xiaobo, Wang Yipeng, Li Jinglong, Guo Lixin, Wu Guangseng, Li Qingui
Department of Minimally Invasive Spine Surgery, The 309th Hospital of The People's Liberation Army, Beijing 100091, P.R. China.
Exp Ther Med. 2019 Nov;18(5):3681-3687. doi: 10.3892/etm.2019.7974. Epub 2019 Sep 5.
It has been reported that tetrahydrocurcumin has hypoglycemic, hypolipidemic, anti-metastasis, anticancer and anti-depressant pharmacological effects, and its antioxidative, hypoglycemic and hypolipidemic properties are better than those of curcumin. The present study assessed whether tetrahydrocurcumin exerts a neuroprotective effect against spinal cord injury (SCI) and investigated the underlying mechanisms. In a rat model of SCI, tetrahydrocurcumin enhanced the average Basso-Beattie-Bresnahan scores, inhibited water accumulation in the spinal cord and decreased inflammatory factors. Furthermore, oxidative stress and apoptosis (caspase-3 activity and B-cell lymphoma 2-associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats.
据报道，四氢姜黄素具有降血糖、降血脂、抗转移、抗癌和抗抑郁等药理作用，其抗氧化、降血糖和降血脂特性优于姜黄素。本研究评估了四氢姜黄素对脊髓损伤（SCI）是否具有神经保护作用，并探讨了其潜在机制。在SCI大鼠模型中，四氢姜黄素提高了Basso-Beattie-Bresnahan平均评分，抑制了脊髓积水并降低了炎症因子。此外，在接受四氢姜黄素治疗的SCI大鼠中，氧化应激和细胞凋亡（半胱天冬酶-3活性和B细胞淋巴瘤-2相关X蛋白水平）也受到抑制。四氢姜黄素有效降低了基质金属蛋白酶-3和-13以及环氧化酶-2的基因表达，促进了Akt的磷酸化，并增强了SCI大鼠中叉头框（FOX）O4的蛋白表达。本研究表明，四氢姜黄素通过调节SCI模型大鼠中的FOXO4来保护脊髓免受损伤并抑制氧化应激反应。
