Al-Naimi Marwa Salih, Rasheed Huda Abdulbaki, Al-Kuraishy Hayder M, Al-Gareeb Ali I
Department of Clinical Pharmacology, Medicine and Therapeutic, Al- Mustansiriya University, Baghdad, Iraq.
J Pak Med Assoc. 2019 Aug;69(Suppl 3)(8):S88-S92.
To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome.
This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance, β- cell function and insulin sensitivity were evaluated.SPSS 20.
Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P<0.01. Olanzapine plus berberine improved body weight, FBG, FSI, HOMA-IR and QUICKI compared with olanzapine P=0.0001.
Berberine attenuates olanzapine induced-metabolic via amelioration of gluco-lipid disturbances.
阐明小檗碱对奥氮平诱导的代谢综合征的保护作用。
本前瞻性实验研究纳入30只雄性Sprague-Dawley大鼠，分为三组。A组（n = 10）：用蒸馏水治疗的大鼠；B组（n = 10）：用奥氮平治疗的大鼠；C组（n = 10）：用奥氮平加小檗碱治疗的大鼠。研究持续时间为8周，评估基线和随访数据。评估空腹血糖（FBG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、血浆致动脉粥样硬化指数（AI）、空腹血清胰岛素水平、胰岛素抵抗、β细胞功能和胰岛素敏感性。使用SPSS 20软件。
与对照组相比，奥氮平导致糖代谢状况显著恶化（P<0.01）。与奥氮平组相比，奥氮平加小檗碱改善了体重、FBG、FSI、HOMA-IR和QUICKI（P = 0.0001）。
小檗碱通过改善糖脂紊乱减轻奥氮平诱导的代谢异常。
