神经元对 2 型固有淋巴细胞和 2 型炎症的调节。
Neuronal regulation of group 2 innate lymphoid cells and type 2 inflammation.
机构信息
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, United States.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, United States; Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, United States.
出版信息
Adv Immunol. 2019;143:1-9. doi: 10.1016/bs.ai.2019.08.001. Epub 2019 Sep 16.
Diverse infectious, inflammatory, and environmental stimuli induce type 2 inflammation in the body. Group 2 innate lymphoid cells (ILC2s) are potent producers of type 2 cytokines and play important roles in promoting type 2 inflammation. In addition to alarmins and other cytokines which are known to regulate ILC2 responses, emerging studies identified the regulation of ILC2s by the nervous system through neurotransmitter and neuropeptides. In this review, we highlight recent advances in the regulation of ILC2s and type 2 inflammation by the nervous system.
多种感染性、炎症性和环境性刺激会在体内诱导 2 型炎症。2 型固有淋巴细胞（ILC2）是 2 型细胞因子的有力产生者，在促进 2 型炎症中发挥重要作用。除了已知调节 ILC2 反应的警报素和其他细胞因子外，新的研究还确定了神经系统通过神经递质和神经肽对 ILC2 的调节。在这篇综述中，我们强调了神经系统对 ILC2 和 2 型炎症的调控的最新进展。
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