Qin Minjing, Fang Yuanyuan, Zheng Qitong, Peng Mengyun, Wang Lu, Sang Xia'nan, Cao Gang
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.
Cell Death Discov. 2024 Jul 16;10(1):324. doi: 10.1038/s41420-024-02096-y.
Type 2 innate lymphoid cells were found to be members of the innate immune cell family, which is involved in innate and adaptive immunity to resist the invasion of foreign antigens and induce allergic reactions caused by allergens. The advancement of ILC2 research has pointed out that ILC2s have a high degree of diversity, challenging the notion of their homogeneity as a cellular population. An increasing number of studies indicate that ILC2 is a cell population with tissue specificity which can be induced by the tissue microenvironment. In addition, crosstalk between tissues can change ILC2 functions of migration and activation. Here, we emphasize that ILC2 undergoes adaptive changes under the regulation of the tissue microenvironment and distant tissues, thereby coordinating the organization's operation. In addition, ILC2 alterations induced by the tissue microenvironment are not limited to the ILC2 cell population, and ILC2 can also transdifferentiate into another class of ILC cell population (ILC1 or ILC3). In this review, we summarized the tissue-specific effects of ILC2 by tissue microenvironment and focused on the function of ILC2 in inter-tissue crosstalk. Lastly, we discussed the transdifferentiations of ILC2 caused by the abnormal change in tissue environment.
2型固有淋巴细胞被发现是固有免疫细胞家族的成员，参与固有免疫和适应性免疫，以抵抗外来抗原的入侵并引发由过敏原引起的过敏反应。ILC2研究的进展指出，ILC2具有高度的多样性，这对其作为一个细胞群体的同质性概念提出了挑战。越来越多的研究表明，ILC2是一个具有组织特异性的细胞群体，可由组织微环境诱导产生。此外，组织间的相互作用可以改变ILC2的迁移和激活功能。在此，我们强调ILC2在组织微环境和远处组织的调节下会发生适应性变化，从而协调机体的运作。此外，由组织微环境诱导的ILC2改变不仅限于ILC2细胞群体，ILC2还可以转分化为另一类ILC细胞群体（ILC1或ILC3）。在这篇综述中，我们总结了组织微环境对ILC2的组织特异性影响，并聚焦于ILC2在组织间相互作用中的功能。最后，我们讨论了组织环境异常变化导致的ILC2转分化。
