Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Front Immunol. 2020 Oct 29;11:576929. doi: 10.3389/fimmu.2020.576929. eCollection 2020.
Emerging evidence supports the involvement of nervous system in the regulation of immune responses. Group 2 innate lymphoid cells (ILC2), which function as a crucial bridge between innate and adaptive immunity, are present in large numbers in barrier tissues. Neuropeptides and neurotransmitters have been found to participate in the regulation of ILC2, adding a new dimension to neuroimmunity. However, a comprehensive and detailed overview of the mechanisms of neural regulation of ILC2, associated with previous findings and prospects for future research, is still lacking. In this review, we compile existing information that supports neurons as yet poorly understood regulators of ILC2 in the field of lung innate and adaptive immunity, focusing on neural regulation of the interaction between ILC2 and pulmonary immune cells.
新兴证据支持神经系统参与免疫反应的调节。2 型固有淋巴细胞（ILC2）作为先天免疫和适应性免疫之间的关键桥梁，大量存在于屏障组织中。神经肽和神经递质被发现参与 ILC2 的调节，为神经免疫增加了一个新的维度。然而，目前仍然缺乏对神经调节 ILC2 的机制的全面、详细的综述，包括与之前的发现和未来研究的前景。在这篇综述中，我们汇编了现有的信息，支持神经元作为肺部先天和适应性免疫领域中 ILC2 尚未被充分了解的调节者，重点关注神经对 ILC2 与肺免疫细胞相互作用的调节。
