Terasaka R, Nomoto K, Himeno K
Immunology. 1979 Dec;38(4):773-9.
Rat tumours grew progressively in nu/nu mice but not in nu/+ mice, normal AKR mice or sublethally irradiated AKR mice after subcutaneous inoculation. Suppression of tumour growth appeared to depend on radioresistant cytotoxic T cells which were detected in in vivo neutralization tests (Winn's test) with spleen cells of mice immunized with rat lymphocytes or tumour cells 5 days previously. Radioresistant cytotoxic activity was detected by 51Cr-release test in glass-non-adherent peritoneal exudate cells 5 days after intraperitoneal immunization with rat lymphocytes. These results suggested that immune lymphocytes might differentiate to mature cytotoxic cells at the site of direct graft rejection.
大鼠肿瘤在皮下接种后,在裸鼠(nu/nu)中呈进行性生长,但在杂合裸鼠(nu/+)、正常AKR小鼠或亚致死剂量照射的AKR小鼠中则不生长。肿瘤生长的抑制似乎取决于放射抗性细胞毒性T细胞,在用大鼠淋巴细胞或肿瘤细胞免疫5天的小鼠脾细胞进行的体内中和试验(温氏试验)中检测到了这些细胞。在用大鼠淋巴细胞进行腹腔免疫5天后,通过51Cr释放试验在玻璃非黏附性腹腔渗出细胞中检测到了放射抗性细胞毒性活性。这些结果表明,免疫淋巴细胞可能在直接移植物排斥部位分化为成熟的细胞毒性细胞。