分化的T细胞亚群之间的关系。V. 异种移植排斥反应的T细胞依赖性机制及其放射抗性本质。

Relationships among differentiated T-cell subpopulations. V. T-cell dependent mechanism of xenograft rejection and its radioresistant nature.

作者信息

Terasaka R, Nomoto K, Himeno K

出版信息

Immunology. 1979 Dec;38(4):773-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457872/

Abstract

Rat tumours grew progressively in nu/nu mice but not in nu/+ mice, normal AKR mice or sublethally irradiated AKR mice after subcutaneous inoculation. Suppression of tumour growth appeared to depend on radioresistant cytotoxic T cells which were detected in in vivo neutralization tests (Winn's test) with spleen cells of mice immunized with rat lymphocytes or tumour cells 5 days previously. Radioresistant cytotoxic activity was detected by 51Cr-release test in glass-non-adherent peritoneal exudate cells 5 days after intraperitoneal immunization with rat lymphocytes. These results suggested that immune lymphocytes might differentiate to mature cytotoxic cells at the site of direct graft rejection.

摘要

大鼠肿瘤在皮下接种后，在裸鼠（nu/nu）中呈进行性生长，但在杂合裸鼠（nu/+）、正常AKR小鼠或亚致死剂量照射的AKR小鼠中则不生长。肿瘤生长的抑制似乎取决于放射抗性细胞毒性T细胞，在用大鼠淋巴细胞或肿瘤细胞免疫5天的小鼠脾细胞进行的体内中和试验（温氏试验）中检测到了这些细胞。在用大鼠淋巴细胞进行腹腔免疫5天后，通过51Cr释放试验在玻璃非黏附性腹腔渗出细胞中检测到了放射抗性细胞毒性活性。这些结果表明，免疫淋巴细胞可能在直接移植物排斥部位分化为成熟的细胞毒性细胞。

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引用本文的文献

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2

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本文引用的文献

1

THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。

J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.

2

Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts.同种移植中的免疫机制。II. 肿瘤同种移植物刺激的淋巴细胞免疫活性的定量测定。

J Immunol. 1961 Feb;86:228-39.

3

Radioresistance of the enhancing effect of cells from carrier-immunized mice in an in vitro primary immune response.载体免疫小鼠细胞在体外初次免疫应答中增强作用的放射抗性。

Proc Natl Acad Sci U S A. 1971 Apr;68(4):699-703. doi: 10.1073/pnas.68.4.699.

4

Acute destruction by humoral antibody of rat skin grafted to mice.移植到小鼠身上的大鼠皮肤被体液抗体急性破坏。

J Immunol. 1973 Jun;110(6):1532-41.

5

Phagocytic cells as effectors in a cell-mediated immunity system.吞噬细胞作为细胞介导免疫系统中的效应细胞。

J Immunol. 1973 Dec;111(6):1844-54.

6

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.带有不同Ly抗原的T淋巴细胞功能亚类。II. Ly+细胞亚类在杀伤活性产生中的合作。

J Exp Med. 1975 Jun 1;141(6):1390-9. doi: 10.1084/jem.141.6.1390.

7

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.带有不同Ly抗原的T淋巴细胞功能亚类。I. 功能不同的T细胞亚类的产生是一个独立于抗原的分化过程。

J Exp Med. 1975 Jun 1;141(6):1376-89. doi: 10.1084/jem.141.6.1376.

8

Acute destruction of rat skin grafts by alloantisera.同种抗血清对大鼠皮肤移植的急性破坏作用。

J Immunol. 1975 Mar;114(3):933-8.

9

Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses.细胞介导的免疫：迟发型超敏反应和细胞毒性反应由不同的T细胞亚类介导。

J Exp Med. 1976 Jun 1;143(6):1534-9. doi: 10.1084/jem.143.6.1534.

10

Experiments on thermodifferential chemotherapy with thoracotomy for blood-borne pulmonary metastasis in rats.大鼠血行性肺转移开胸热差化疗实验

Gan. 1977 Apr;68(2):165-74.

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