Millard R E, Banerjee D K
J Clin Pathol. 1979 Oct;32(10):1045-9. doi: 10.1136/jcp.32.10.1045.
The blood lymphocytes of 37 splenectomised patients were analysed by means of T and B lymphocyte surface markers. Sixteen patients had had a splenectomy for non-haematological and 21 for haematological reasons. The results show that 15 had normal numbers of T and B cells; decreased T cells were found in two patients, raised B cells in seven, raised T and B cells in eight, and raised T cells in five patients. Increased numbers of 'null' cells were observed in some patients, especially in those with raised B cells. Follow-up studies indicate that raised levels of T and B cells can be established by one to three months post-splenectomy and may persist, although in some patients the cells fall to normal levels. The lymphocyte proliferative response to phytohaemagglutinin and Concanavalin A in vitro was normal in eight out of nine patients with raised T cells and was depressed in one patient, possibly due to an intrinsic cell defect.
通过T和B淋巴细胞表面标志物对37例脾切除患者的血液淋巴细胞进行了分析。16例患者因非血液学原因接受脾切除术，21例因血液学原因接受脾切除术。结果显示，15例患者的T细胞和B细胞数量正常；2例患者T细胞减少，7例患者B细胞增多，8例患者T细胞和B细胞均增多，5例患者T细胞增多。在一些患者中观察到“无标记”细胞数量增加，尤其是B细胞增多的患者。随访研究表明，脾切除术后1至3个月可出现T细胞和B细胞水平升高，且可能持续存在，尽管在一些患者中细胞会降至正常水平。9例T细胞增多的患者中有8例对植物血凝素和刀豆球蛋白A的体外淋巴细胞增殖反应正常，1例患者反应降低，可能是由于内在细胞缺陷。
