Mechergui Arij, Achour Wafa, Mathlouthi Sondos, Hassen Assia Ben
The National Bone Marrow Transplant Center, 1006, Tunis, Tunisia.
Faculty of Medicine of Tunis, UR12ES02, 1007, Tunis, Tunisia.
Afr Health Sci. 2019 Jun;19(2):2021-2025. doi: 10.4314/ahs.v19i2.25.
A retrospective study was conducted in the Bone Marrow Transplant Center of Tunisia during a period of 10 years (from 2002 to 2011) in order to report the prevalence of infectious multi-drug resistant bacteria.
Bacterial identification was carried on the basis of biochemical characteristics and API identification systems. Antibiotic susceptibility was tested by disc diffusion method on Muller-Hinton agar.
During the study period, 34.5% of 142 strains and 11.46% of 218 strains were extended-spectrum beta-lactamase (ESBL) producers. Also, 32.8% of 210 strains of were imipenem and/or ceftazidime resistant and 20.75% of 106 strains of were methicillin resistant. A rising trend was observed for the prevalence of the selected multidrug resistant bacteria.
These findings may have important clinical implications in prophylaxis and selection of antibiotic treatment. Continuous surveillance is needed, especially for onco-hematological patients.
在突尼斯骨髓移植中心进行了一项为期10年（2002年至2011年）的回顾性研究，以报告多重耐药性感染细菌的流行情况。
根据生化特性和API鉴定系统进行细菌鉴定。采用纸片扩散法在Muller-Hinton琼脂上检测抗生素敏感性。
在研究期间，142株菌株中有34.5%、218株菌株中有11.46%为超广谱β-内酰胺酶（ESBL）产生菌。此外，210株菌株中有32.8%对亚胺培南和/或头孢他啶耐药，106株菌株中有20.75%对甲氧西林耐药。所选多重耐药细菌的流行率呈上升趋势。
这些发现可能对预防和选择抗生素治疗具有重要的临床意义。需要持续监测，尤其是对肿瘤血液学患者。
