Zahed Maryam, Safvat Mojtaba, Bazargani Abdollah, Ghapanchi Janan, Ranjbar Zahra
Oral and Dental Disease Research Center, Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Undergraduate Student, Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
J Dent (Shiraz). 2025 Mar 1;26(1):17-24. doi: 10.30476/dentjods.2024.100492.2225. eCollection 2025 Mar.
Opportunistic infections such as , colonized from the oral cavity, are common in candidates of bone marrow transplantation. Therefore, it is important to prescribe appropriate antibiotics for this group of debilitated patients.
In this study, we aimed to investigate the antibiotic resistance to encountered in candidates of bone marrow transplantation referred to Imam Reza Clinic, Namazi Hospital, and Amir Hospital, Shiraz, Iran.
This cross-sectional study was performed on 30 patients with leukemia and lymphoma. To identify Pseudomonas species, saliva samples were collected and cultured in a blood agar medium. Considering the present therapies, we examined the antibiotic sensitivity of Penicillin, Oxacillin, Gentamicin, Tetracycline, Cefepime, Ciprofloxacin, Imipenem, Ceftazidime, Cefotaxime, Erythromycin, Trimethoprim, Sulfamethoxazole, and Vancomycin. Statistical analysis was performed using chi-square test (χ) and SPSS software. The Value< 0.05 was considered significant.
In 10 patients out of 30 for whom was found positive (33.33%), all cultures were resistant to Penicillin and Oxacillin (100%), followed by Trimethoprim and Sulfamethoxazole (80%). The best performance was seen by Vancomycin (20%). No correlation was found in terms of age, gender, and type of disease (lymphoma or leukemia) for antibiotic resistance (> 0.05).
It seems that Penicillin, Oxacillin, Tetracycline, Sulfamethoxazole have significant resistance to Pseudomonas aeruginosa. Further research on Gentamicin, Ceftazidime, Ciprofloxacin, and especially Vancomycin is recommended for effective antibiotic prescriptions against .
诸如从口腔定植的机会性感染在骨髓移植候选者中很常见。因此，为这组虚弱患者开具合适的抗生素很重要。
在本研究中，我们旨在调查转诊至伊朗设拉子伊玛目礼萨诊所、纳马齐医院和阿米尔医院的骨髓移植候选者中遇到的对[具体病菌名称未给出]的抗生素耐药性。
本横断面研究对30例白血病和淋巴瘤患者进行。为鉴定假单胞菌属菌种，收集唾液样本并在血琼脂培养基中培养。考虑到当前的治疗方法，我们检测了青霉素、苯唑西林、庆大霉素、四环素、头孢吡肟、环丙沙星、亚胺培南、头孢他啶、头孢噻肟、红霉素、甲氧苄啶、磺胺甲恶唑和万古霉素的抗生素敏感性。使用卡方检验（χ）和SPSS软件进行统计分析。P值<0.05被认为具有显著性。
在30例检测出[具体病菌名称未给出]呈阳性的患者中，有10例（33.33%），所有培养物对青霉素和苯唑西林均耐药（100%），其次是甲氧苄啶和磺胺甲恶唑（80%）。万古霉素的表现最佳（20%）。在抗生素耐药性方面，未发现年龄、性别和疾病类型（淋巴瘤或白血病）之间存在相关性（P>0.05）。
似乎青霉素、苯唑西林、四环素、磺胺甲恶唑对铜绿假单胞菌具有显著耐药性。建议对庆大霉素、头孢他啶、环丙沙星，尤其是万古霉素进行进一步研究，以开出针对[具体病菌名称未给出]的有效抗生素处方。
