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中国北方地区人感染新型欧亚禽源猪 H1N1 病毒。

Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China.

机构信息

Tianjin Centers for Disease Control and Prevention, Tianjin, People's Republic of China.

Jizhou District Center for Disease Control and Prevention, Tianjin, People's Republic of China.

出版信息

Emerg Microbes Infect. 2019;8(1):1535-1545. doi: 10.1080/22221751.2019.1679611.

DOI:10.1080/22221751.2019.1679611
PMID:31661383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6830285/
Abstract

Influenza A virus infections occur in different species, causing mild to severe respiratory symptoms that lead to a heavy disease burden. Eurasian avian-like swine influenza A(H1N1) viruses (EAS-H1N1) are predominant in pigs and occasionally infect humans. An influenza A(H1N1) virus was isolated from a boy who was suffering from fever and headache and designated as A/Tianjin-baodi/1606/2018(H1N1). Full-genome sequencing and phylogenetic analysis revealed that A/Tianjin-baodi/1606/2018(H1N1) is a novel reassortant EAS-H1N1 containing gene segments from EAS-H1N1 (HA and NA), classical swine H1N1(NS) and A(H1N1)pdm09(PB2, PB2, PA, NP and M) viruses. The isolation and analysis of A/Tianjin-baodi/1606/2018(H1) provide further evidence that EAS-H1N1 poses a threat to human health and greater attention should be paid to surveillance of influenza virus infection in pigs and humans.

摘要

甲型流感病毒感染发生在不同的物种中，引起轻度至重度呼吸道症状，导致沉重的疾病负担。欧亚类禽源性猪流感 A(H1N1)病毒（EAS-H1N1）在猪中占优势，偶尔感染人类。从一名发烧和头痛的男孩身上分离到一株甲型流感 A(H1N1)病毒，并将其命名为 A/Tianjin-baodi/1606/2018(H1N1)。全基因组测序和系统进化分析显示，A/Tianjin-baodi/1606/2018(H1N1)是一种新型的 EAS-H1N1 重配病毒，包含 EAS-H1N1（HA 和 NA）、经典猪源 H1N1（NS）和 A(H1N1)pdm09（PB2、PB2、PA、NP 和 M）病毒的基因片段。A/Tianjin-baodi/1606/2018(H1)的分离和分析进一步证明了 EAS-H1N1 对人类健康构成威胁，应更加关注猪和人类流感病毒感染的监测。

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