Department of Chemistry, Korea University, Seoul 02841, Republic of Korea.
Nat Prod Rep. 2020 Apr 1;37(4):477-487. doi: 10.1039/c9np00046a. Epub 2019 Oct 29.
Covering: 1994 to 2019Owing to the rapid increase in nosocomial infections by antibiotic-resistant Acinetobacter baumannii and the paucity of effective treatment options for such infections, interest in the virulence factors involved in its successful dissemination and propagation in the human host have escalated in recent years. Acinetobacin, a siderophore of A. baumannii, is responsible for iron acquisition under nutritional depravation and has been shown to be one of the key virulence factors for this bacterium. In this Highlight, recent findings regarding various chemical and biological aspects of acinetobactin metabolism closely related to the fitness of A. baumannii at the infection sites have been described. In addition, several notable efforts for identifying novel anti-infectious agents based thereon have been discussed.
1994 年至 2019 年
由于耐抗生素鲍曼不动杆菌引起的医院感染迅速增加，而对于此类感染的有效治疗方法却相对匮乏，近年来，人们对其在人体宿主中成功传播和繁殖所涉及的毒力因子的兴趣日益浓厚。鲍曼不动杆菌的铁载体，即阿非菌素，负责在营养剥夺下获取铁，并且已被证明是该细菌的关键毒力因子之一。在本要点中，描述了与感染部位鲍曼不动杆菌适应性密切相关的阿非菌素代谢的各个化学和生物学方面的最新发现。此外，还讨论了基于这些发现鉴定新型抗感染药物的一些重要努力。
