Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
Section of Nutrition and Metabolism, International Agency for Research on Cancer. Lyon, France.
Salud Publica Mex. 2019 Sep-Oct;61(5):601-608. doi: 10.21149/10466.
To describe the rationale and the methodology of a multicenter project to study the etiology of breast cancer in young Latin American women.
The International Agency for Research on Cancer has established an international collaborative population-based case-control study in four countries in Latin America: Chile, Colombia, Costa Rica, and Mexico (the PRECAMA study). Standardized methodologies were developed to collect information on reproductive variables, lifestyle, anthropometry, diet, clinical and pathological data, and biological specimens. The study will be extended to other countries in the region.
PRECAMA is unique in its multidisciplinary approach that combines genetics, genomics, and metabolomics with lifestyle factors. Then data generated through this project will be instrumental to identify major risk factors for molecular subtypes of breast cancer in young women, which will be important for pre- vention and targeted screening programs in Latin America.
描述一个多中心项目的基本原理和方法，该项目旨在研究拉丁美洲年轻女性乳腺癌的病因。
国际癌症研究机构在拉丁美洲的四个国家（智利、哥伦比亚、哥斯达黎加和墨西哥）建立了一个基于人群的国际合作病例对照研究（PRECAMA 研究）。制定了标准化的方法来收集有关生殖变量、生活方式、人体测量学、饮食、临床和病理数据以及生物样本的信息。该研究将扩展到该地区的其他国家。
PRECAMA 的独特之处在于其多学科方法，将遗传学、基因组学和代谢组学与生活方式因素相结合。然后，通过该项目生成的数据将有助于确定年轻女性乳腺癌分子亚型的主要危险因素，这对于拉丁美洲的预防和有针对性的筛查计划将非常重要。
