Department of Public Health Sciences, UC Davis Comprehensive Cancer Center, University of California Davis, Davis, California.
Department of Population Health Sciences, School of Medicine, Mays Cancer Center, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Cancer Epidemiol Biomarkers Prev. 2022 May 4;31(5):932-941. doi: 10.1158/1055-9965.EPI-21-1303.
The Hispanic/Latino(x) population (H/L) in the United States of America is heterogeneous and fast growing. Cancer is the number one cause of death among H/Ls, accounting for 21% of deaths. Whereas for the most common cancers, incidence rates are lower in H/Ls compared with non-H/L White (NHW) individuals, H/Ls have a higher incidence of liver, stomach, cervical, penile, and gallbladder cancers. H/L patients tend to be diagnosed at more advanced stages for breast, colorectal, prostate, and lung cancers, and melanoma compared with NHW individuals. Etiologic and cancer outcomes research among H/Ls lags other populations. In this review, we provide a summary of challenges, opportunities, and research priorities related to cancer etiology, cancer outcomes, and survivorship to make progress in addressing scientific gaps. Briefly, we prioritize the need for more research on determinants of obesity, nonalcoholic fatty liver disease and its progression to liver cancer, stomach and gallbladder cancers, and pediatric acute lymphoblastic leukemia. We emphasize the need to improve cancer screening, early detection of cancer, and survivorship care. We highlight critical resources needed to make progress in cancer epidemiologic studies among H/L populations, including the importance of training the next generation of cancer epidemiologists conducting research in H/Ls.
美国的西班牙裔/拉丁裔(H/L)人口具有异质性且增长迅速。癌症是 H/L 人群的头号死因,占死亡人数的 21%。虽然 H/L 人群中最常见癌症的发病率低于非西班牙裔白人(NHW)人群,但 H/L 人群的肝癌、胃癌、宫颈癌、阴茎癌和胆囊癌发病率更高。与 NHW 人群相比,H/L 患者的乳腺癌、结直肠癌、前列腺癌和肺癌以及黑色素瘤的诊断往往处于更晚期。H/L 人群的病因和癌症结局研究落后于其他人群。在这篇综述中,我们提供了与癌症病因、癌症结局和生存相关的挑战、机遇和研究重点的总结,以在解决科学差距方面取得进展。简而言之,我们优先考虑需要更多研究肥胖、非酒精性脂肪性肝病及其向肝癌的进展、胃癌和胆囊癌以及儿科急性淋巴细胞白血病的决定因素。我们强调需要改善癌症筛查、癌症的早期检测和生存护理。我们强调了在 H/L 人群中进行癌症流行病学研究所需的关键资源,包括培养下一代在 H/L 人群中进行研究的癌症流行病学家的重要性。