细胞外囊泡作为天然、安全且高效的药物递送系统
Extracellular Vesicles as Natural, Safe and Efficient Drug Delivery Systems.
作者信息
Villa Federico, Quarto Rodolfo, Tasso Roberta
机构信息
U.O. Cellular Oncology, Ospedale Policlinico San Martino, 16132 Genova, Italy.
Department of Experimental Medicine, University of Genova, 16132 Genova, Italy.
出版信息
Pharmaceutics. 2019 Oct 28;11(11):557. doi: 10.3390/pharmaceutics11110557.
Abstract
Extracellular vesicles (EVs) are particles naturally released from cells, delimited by a lipid bilayer, carrying functionally active biological molecules. In addition to their physiological role in cellular communication, the interest of the scientific community has recently turned to the use of EVs as vehicles for delivering therapeutic molecules. Several attempts are being made to ameliorate drug encapsulation and targeting, but these efforts are thwarted if the starting material does not meet stringent quality criteria. Here, we take a step back to the sources and isolation procedures that could guarantee significant improvements in the purification of EVs to be used as drug carriers, highlighting the advantages and shortcomings of each approach.
摘要
细胞外囊泡（EVs）是细胞自然释放的颗粒，由脂质双层界定，携带具有功能活性的生物分子。除了在细胞通讯中的生理作用外，科学界最近的兴趣转向了将EVs用作递送治疗性分子的载体。人们正在进行多项尝试来改善药物封装和靶向性，但如果起始材料不符合严格的质量标准，这些努力就会受到阻碍。在这里，我们退回到能够保证显著改善用作药物载体的EVs纯化的来源和分离程序，突出每种方法的优缺点。
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