Namas Rajaie, Joshi Abhay, Ali Zarmeena, Al Saleh Jamal, Abuzakouk Mohammed
Division of Rheumatology, Department of Internal Medicine, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Dubai Hospital, Dubai, UAE.
Int J Rheumatol. 2019 Sep 25;2019:3057578. doi: 10.1155/2019/3057578. eCollection 2019.
This retrospective cohort study aimed to assess the demographic and clinical characteristics of rheumatoid arthritis (RA) in Emirati patients attending Cleveland Clinic Abu Dhabi, a large tertiary center in the Middle East. In this study, 414 Emirati patients with RA were evaluated over a 3-year period from April 2015 to April 2018. All patients fulfilled the 2010 RA ACR/EULAR criteria and were assessed for demographic and clinical characteristics. The estimated RA prevalence rate in our population cohort was 2.72%. Females showed predominance (80%) with a higher body mass index (31.4 ± 6.61, = 0.0001) compared to males (28.8 ± 6.03, = 0.0001). The most frequent comorbidity observed was dyslipidemia (43.5%) followed by hypertension (37.9%), diabetes mellitus (34.5%), and gastroesophageal reflux disease (33.1%). Xerophthalmia was the most frequent extra-articular manifestation. Rheumatoid factor and anti-citrullinated peptide were detected in 63.3% and 41.5% patients, respectively, while both were present in 33.3% of patients. Methotrexate, adalimumab, and rituximab were the most frequently prescribed disease modifying agents. In this study, we describe disease features that are unique to United Arab Emirates (UAE) patients and demonstrate that RA has a significant disease burden. Our findings highlight the need for a RA national registry to improve the quality of care of these patients in UAE.
这项回顾性队列研究旨在评估在中东一家大型三级医疗中心——阿布扎比克利夫兰诊所就诊的阿联酋类风湿关节炎（RA）患者的人口统计学和临床特征。在本研究中，从2015年4月至2018年4月的3年期间对414例阿联酋RA患者进行了评估。所有患者均符合2010年RA美国风湿病学会/欧洲抗风湿病联盟（ACR/EULAR）标准，并对其人口统计学和临床特征进行了评估。我们人群队列中RA的估计患病率为2.72%。女性占主导（80%），与男性（28.8±6.03，P = 0.0001）相比，女性体重指数更高（31.4±6.61，P = 0.0001）。观察到最常见的合并症是血脂异常（43.5%），其次是高血压（37.9%）、糖尿病（34.5%）和胃食管反流病（33.1%）。干眼症是最常见的关节外表现。类风湿因子和抗瓜氨酸化肽分别在63.3%和41.5%的患者中检测到，而两者均存在于33.3%的患者中。甲氨蝶呤、阿达木单抗和利妥昔单抗是最常处方的改善病情药物。在本研究中，我们描述了阿联酋（UAE）患者特有的疾病特征，并证明RA具有重大的疾病负担。我们的研究结果强调了在阿联酋建立RA国家登记系统以提高这些患者护理质量的必要性。
