Bieliu Nas Vidmantas, De Borggraeve Wim M
Molecular Design and Synthesis, Department of Chemistry , KU Leuven , Celestijnenlaan 200F , Box 2404, 3001 Leuven , Belgium.
J Org Chem. 2019 Dec 6;84(23):15706-15717. doi: 10.1021/acs.joc.9b02352. Epub 2019 Nov 12.
Application of activated phenol fluorosulfates as substrates in a Pd/NBE mediated sequential alkylation-arylation, commonly known as a Catellani reaction, is presented. These substrates provide a level of complementarity to the commonly used aryl halides and, in combination with a plethora of existing Catellani reaction variations, enable even wider application of this powerful synthetic tool.
