甾醇酸油对果糖诱导的大鼠代谢综合征发展的预防作用。
Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model.
机构信息
National Tech of México (Tecnológico Nacional de México)/I.T. Veracruz, Food Research and Development Unit (UNIDA), Veracruz, México.
Institute of Psychological Research, University of Veracruz, Xalapa, Veracruz, México.
出版信息
J Med Food. 2020 Mar;23(3):305-311. doi: 10.1089/jmf.2019.0177. Epub 2019 Oct 30.
The metabolic syndrome (MS) underlies metabolic disorders considered risk factors for the development of diabetes and cardiovascular diseases, which are major causes of morbidity and mortality in most of the world. Sterculic acid has been proposed as a potential tool for the treatment of MS since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1), a central enzyme in lipid metabolism. We analyzed the effect of sterculic oil (SO) co-administration with 30% fructose in drinking water on the development of MS in male Wistar rats. After 8 weeks, 0.4% SO exerted a protective effect from MS development since parameters altered by fructose (blood pressure, insulin resistance, serum glucose and triglycerides, steatosis, and adiposity) were similar to those of control rats.
代谢综合征（MS）是多种代谢紊乱的综合病症，这些代谢紊乱被认为是引发糖尿病和心血管疾病的风险因素，而后者是世界上大多数地区发病率和死亡率的主要原因。硬脂酸已被提议作为治疗 MS 的一种潜在手段，因为它可以抑制硬脂酰辅酶 A 去饱和酶-1（SCD1）的活性，而 SCD1 是脂质代谢的关键酶。我们分析了在饮水中添加 30%果糖的情况下，硬脂酸油（SO）共同给药对雄性 Wistar 大鼠 MS 发展的影响。8 周后，0.4%的 SO 对 MS 的发展具有保护作用，因为果糖改变的参数（血压、胰岛素抵抗、血清葡萄糖和甘油三酯、脂肪变性和肥胖）与对照组大鼠相似。
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