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大鼠代谢综合征模型的建立：综述

Development of rat metabolic syndrome models: A review.

作者信息

Gunawan Shirly, Aulia Ahmad, Soetikno Vivian

机构信息

Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia.

Doctoral Programme in Biomedical Science Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

出版信息

Vet World. 2021 Jul;14(7):1774-1783. doi: 10.14202/vetworld.2021.1774-1783. Epub 2021 Jul 7.

DOI:10.14202/vetworld.2021.1774-1783
PMID:34475697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8404106/
Abstract

Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study.

摘要

代谢综合征（MetS）已成为一个全球性问题。随着全球范围内MetS患病率的不断上升，了解其发病机制和治疗方式至关重要。动物模型应能恰当体现人类疾病的临床表现。大鼠是研究中最常用的实验动物。利用大鼠建立合适的MetS模型将有助于研究结果在临床环境中的成功应用。人们采用各种干预方法，通过使用各种成分的饮食诱导、化学物质或两者结合来诱发MetS。本综述将全面概述几项关于大鼠MetS模型建立的研究，以及每项研究产生的临床表现特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/0646f3053684/Vetworld-14-1774-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/6e0e853dac4f/Vetworld-14-1774-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/1beb7bdae490/Vetworld-14-1774-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/681fe77c42b6/Vetworld-14-1774-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/de88c8dcc4ee/Vetworld-14-1774-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/0646f3053684/Vetworld-14-1774-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/6e0e853dac4f/Vetworld-14-1774-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/1beb7bdae490/Vetworld-14-1774-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/681fe77c42b6/Vetworld-14-1774-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/de88c8dcc4ee/Vetworld-14-1774-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fd9/8404106/0646f3053684/Vetworld-14-1774-g005.jpg

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