新型头孢菌素SCE - 129的体外抗菌活性及β - 内酰胺酶稳定性
In vitro antibacterial activity and beta-lactamase stability of SCE-129, a new cephalosporin.
作者信息
Neu H C, Fu K P
出版信息
Antimicrob Agents Chemother. 1979 May;15(5):646-50. doi: 10.1128/AAC.15.5.646.
SCE-129 [3-4-carbamoyl-1-pyridiniomethyl-7beta- (d-alpha-sulfophenylacetamido)-ceph-3-em-4-carboxylate] is a cephalosporin that inhibits Pseudomonas aeruginosa and Staphylococcus aureus. SCE-129 is tenfold more active than carbenicillin in inhibiting P. aeruginosa. SCE-129 has poor activity against Enterobacteriaceae compared with other cephalosporins and is 16-fold less active than the cephalosporins against streptococci. The activity of SCE-129 does not correlate with beta-lactamase stability, although SCE-129 is resistant to hydrolysis by gram-positive and gram-negative bacteria. The compound does not inhibit the hydrolysis of other cephalosporins. Although SCE-129 acts synergistically with gentamicin to inhibit some Pseudomonas, this cannot be predicted based on knowledge of resistance to one or more compounds.
SCE - 129 [3 - 4 - 氨甲酰基 - 1 - 吡啶甲基 - 7β - （d - α - 磺基苯乙酰氨基） - 头孢 - 3 - 烯 - 4 - 羧酸酯] 是一种抑制铜绿假单胞菌和金黄色葡萄球菌的头孢菌素。SCE - 129在抑制铜绿假单胞菌方面的活性比羧苄西林高10倍。与其他头孢菌素相比，SCE - 129对肠杆菌科细菌的活性较差，且对链球菌的活性比头孢菌素低16倍。尽管SCE - 129对革兰氏阳性菌和革兰氏阴性菌的水解具有抗性，但其活性与β - 内酰胺酶稳定性无关。该化合物不抑制其他头孢菌素的水解。虽然SCE - 129与庆大霉素协同作用抑制某些铜绿假单胞菌，但这不能基于对一种或多种化合物的抗性知识来预测。
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