抗生素与体外淋巴细胞功能的抑制
Antibiotics and suppression of lymphocyte function in vitro.
作者信息
Banck G, Forsgren A
出版信息
Antimicrob Agents Chemother. 1979 Nov;16(5):554-60. doi: 10.1128/AAC.16.5.554.
Abstract
The effects on the mitogenic response of human T lymphocytes were studied for 20 different antibiotics. No apparent inhibitory effect could be detected for penicillins, cephalosporins, aminoglycosides, chloramphenicol, sulfamethoxazole, trimethoprim, nalidixic acid, and 5-fluorocytosine. There were effects at high concentrations with erythromycin, clindamycin, and rifampin, and these antibiotics could also be shown to depress the mitogenic response of B lymphocytes. With fusidic acid, nitrofurantoin, and doxycycline there was an inhibiting effect at low concentrations on the mitogenic responses of B and T lymphocytes and on in vitro antibody production. Protein synthesis in unstimulated lymphocytes was also inhibited. Some antibiotics thus may impair the function of human lymphocytes in vitro.
摘要
研究了20种不同抗生素对人T淋巴细胞促有丝分裂反应的影响。青霉素、头孢菌素、氨基糖苷类、氯霉素、磺胺甲恶唑、甲氧苄啶、萘啶酸和5-氟胞嘧啶未检测到明显的抑制作用。红霉素、克林霉素和利福平在高浓度时有作用，这些抗生素也可降低B淋巴细胞的促有丝分裂反应。夫西地酸、呋喃妥因和多西环素在低浓度时对B和T淋巴细胞的促有丝分裂反应以及体外抗体产生有抑制作用。未受刺激的淋巴细胞中的蛋白质合成也受到抑制。因此，一些抗生素可能会在体外损害人淋巴细胞的功能。
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