Adler-Neal Adrienne L, Cline Abigail, Frantz Travis, Strowd Lindsay, Feldman Steven R, Taylor Sarah
Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Children (Basel). 2019 Oct 30;6(11):121. doi: 10.3390/children6110121.
Childhood atopic dermatitis is a chronic inflammatory skin condition that causes significant psychological and financial costs to the individual and society. Treatment regimens may require long-term medication adherence and can be associated with poor patient satisfaction. There is considerable interest in complementary and integrative medicine (CIM) approaches for childhood atopic dermatitis.
To assess the effects of CIM approaches on childhood atopic dermatitis outcomes as defined by randomized, controlled clinical trials.
A PubMed review of CIM-related treatments for pediatric atopic dermatitis was performed, and data related to age, study population, efficacy, treatment regimen, length of treatment, and sample size were included.
The search yielded 20 trials related to probiotic/prebiotic treatments for atopic dermatitis, three on the effects of vitamins on children with atopic dermatitis, and two on the effects of Chinese herbal treatments for atopic dermatitis in children and adolescents. The strongest evidence was for supplementation with the probiotics and .
Certain strains of probiotics, specifically and may improve clinical severity scores in children with atopic dermatitis. However, additional trials are needed to more thoroughly delineate the effects of additional integrative therapies on childhood atopic dermatitis.
儿童特应性皮炎是一种慢性炎症性皮肤病，给个人和社会带来巨大的心理和经济负担。治疗方案可能需要长期坚持用药，且患者满意度较低。人们对儿童特应性皮炎的补充和整合医学（CIM）方法兴趣浓厚。
通过随机对照临床试验评估CIM方法对儿童特应性皮炎结局的影响。
对PubMed上有关儿童特应性皮炎的CIM相关治疗进行综述，并纳入与年龄、研究人群、疗效、治疗方案、治疗时长和样本量相关的数据。
检索到20项关于益生菌/益生元治疗特应性皮炎的试验，3项关于维生素对特应性皮炎儿童影响的试验，以及2项关于中药治疗儿童和青少年特应性皮炎影响的试验。最有力的证据是补充益生菌和。
某些益生菌菌株，特别是和，可能改善特应性皮炎儿童的临床严重程度评分。然而，需要更多试验来更全面地描述其他整合疗法对儿童特应性皮炎的影响。
