Khazdair Mohammad Reza, Anaeigoudari Akbar, Kianmehr Majid
Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran.
Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
J Pharmacopuncture. 2019 Sep;22(3):122-130. doi: 10.3831/KPI.2019.22.016. Epub 2019 Sep 30.
The medicinal plants are believed to enhance the natural resistance of the body to infections. Some of the main constituents of the plant and derived materials such as, proteins, lectins and polysaccharides have anti-inflammatory effects. Portulaca oleracea (P. oleracea) were used traditionally for dietary, food additive, spice and various medicinal purposes. This review article is focus on the anti-asthmatic effects of P. oleracea and its constituents.
Various databases, such as the PubMed, Scopus, and Google Scholar, were searched the keywords including "Portulaca oleracea", "Quercetin", "Anti-inflammatory", "Antioxidant", "Cytokines", "Smooth muscle ", and " Relaxant effects " until the end of Jul 2018.
P. oleracea extracts and its constituents increased IFN-γ, IL-2, IFNγ/IL-4 and IL- 10/IL-4 ratio, but decreased secretion of TNF-α, IL-4 and chemokines in both in vitro and in vivo studies. P. oleracea extracts and quercetin also significantly decreased production of NO, stimulated β-adrenoceptor and/or blocking muscarinic receptors in tracheal smooth muscles. Conclusion: P. oleracea extracts and quercetin showed relatively potent anti-asthmatic effects due to decreased production of NO, inflammatory cytokines and chemokines, reduced oxidant while enhanced antioxidant markers, and also showed potent relaxant effects on tracheal smooth muscles via stimulatory on β-adrenoceptor or/and blocking muscarinic receptors.
药用植物被认为可增强机体对感染的天然抵抗力。该植物及其衍生材料的一些主要成分，如蛋白质、凝集素和多糖具有抗炎作用。马齿苋传统上用于饮食、食品添加剂、香料及各种药用目的。这篇综述文章聚焦于马齿苋及其成分的抗哮喘作用。
检索了各种数据库，如PubMed、Scopus和谷歌学术，搜索关键词包括“马齿苋”、“槲皮素”、“抗炎”、“抗氧化剂”、“细胞因子”、“平滑肌”和“舒张作用”，检索截至2018年7月底。
在体外和体内研究中，马齿苋提取物及其成分均增加了IFN-γ、IL-2、IFNγ/IL-4和IL-10/IL-4的比例，但降低了TNF-α、IL-4和趋化因子的分泌。马齿苋提取物和槲皮素还显著降低了气管平滑肌中NO的产生，刺激β-肾上腺素能受体和/或阻断毒蕈碱受体。结论：马齿苋提取物和槲皮素显示出相对较强的抗哮喘作用，这是由于它们降低了NO、炎性细胞因子和趋化因子的产生，减少了氧化剂同时增强了抗氧化标志物，并且通过刺激β-肾上腺素能受体或/和阻断毒蕈碱受体对气管平滑肌显示出强大的舒张作用。
