作为抗癌治疗靶点的三维基因组
The 3D Genome as a Target for Anticancer Therapy.
作者信息
Kantidze Omar L, Gurova Katerina V, Studitsky Vasily M, Razin Sergey V
机构信息
Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
出版信息
Trends Mol Med. 2020 Feb;26(2):141-149. doi: 10.1016/j.molmed.2019.09.011. Epub 2019 Oct 31.
Abstract
The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers. We discuss potential connections of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of action of 3D genome-disrupting drugs. Finally, we highlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affecting 3D genome organization.
摘要
三维基因组组织在基因表达精确调控中的作用已得到充分证实。因此，三维基因组改变与疾病发展之间的机制联系正变得越来越明显。这篇观点文章简要介绍了我们目前对与癌症相关的三维基因组改变的理解。我们讨论了三维基因组与癌症转录成瘾现象的潜在联系以及三维基因组破坏药物的分子作用机制。最后，我们强调了发现第一种强烈影响三维基因组组织的药物所引发的问题和观点。
相似文献
1
The 3D Genome as a Target for Anticancer Therapy.作为抗癌治疗靶点的三维基因组
Trends Mol Med. 2020 Feb;26(2):141-149. doi: 10.1016/j.molmed.2019.09.011. Epub 2019 Oct 31.
2
On Epigenetic Plasticity and Genome Topology.关于表观遗传可塑性和基因组拓扑结构。
Trends Cancer. 2020 Mar;6(3):177-180. doi: 10.1016/j.trecan.2020.01.006. Epub 2020 Feb 7.
3
Epigenomics in 3D: importance of long-range spreading and specific interactions in epigenomic maintenance.三维组学：长程扩散和特定相互作用在表观基因组维持中的重要性。
Nucleic Acids Res. 2018 Mar 16;46(5):2252-2264. doi: 10.1093/nar/gky009.
4
The role of 3D chromatin domains in gene regulation: a multi-facetted view on genome organization.3D 染色质域在基因调控中的作用：对基因组组织的多角度观察。
Curr Opin Genet Dev. 2020 Apr;61:1-8. doi: 10.1016/j.gde.2020.02.015. Epub 2020 Mar 19.
5
The role of 3D genome organization in development and cell differentiation.三维基因组组织在发育和细胞分化中的作用。
Nat Rev Mol Cell Biol. 2019 Sep;20(9):535-550. doi: 10.1038/s41580-019-0132-4.
6
Chromatin-driven behavior of topologically associating domains.染色质驱动的拓扑关联域的行为。
J Mol Biol. 2015 Feb 13;427(3):608-25. doi: 10.1016/j.jmb.2014.09.013. Epub 2014 Oct 2.
7
The anti-cancer drugs curaxins target spatial genome organization.抗癌药物 curaxin 靶向空间基因组组织。
Nat Commun. 2019 Mar 29;10(1):1441. doi: 10.1038/s41467-019-09500-7.
8
Targeting Epigenetics in Cancer.靶向治疗癌症的表观遗传学。
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:187-207. doi: 10.1146/annurev-pharmtox-010716-105106. Epub 2017 Oct 6.
9
A tour of 3D genome with a focus on CTCF.聚焦于 CTCF 的 3D 基因组巡礼。
Semin Cell Dev Biol. 2019 Jun;90:4-11. doi: 10.1016/j.semcdb.2018.07.020. Epub 2018 Jul 23.
10
Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery.核周层粘连蛋白将基因组组织成全局三维结构。
Mol Cell. 2018 Sep 6;71(5):802-815.e7. doi: 10.1016/j.molcel.2018.05.017. Epub 2018 Jun 28.
引用本文的文献
1
Ectopic Recruitment of the CTCF N-Terminal Domain with Two Proximal Zinc-Finger Domains as a Tool for 3D Genome Engineering.将CTCF N端结构域与两个近端锌指结构域异位招募作为3D基因组工程的一种工具
Int J Mol Sci. 2025 Aug 1;26(15):7446. doi: 10.3390/ijms26157446.
2
Unveiling Alterations of Epigenetic Modifications and Chromatin Architecture Leading to Lipid Metabolic Reprogramming during the Evolutionary Trastuzumab Adaptation of HER2-Positive Breast Cancer.揭示表观遗传修饰和染色质结构的改变，导致 HER2 阳性乳腺癌在进化性曲妥珠单抗适应过程中的脂质代谢重编程。
Adv Sci (Weinh). 2024 May;11(18):e2309424. doi: 10.1002/advs.202309424. Epub 2024 Mar 9.
3
Cohesin regulation and roles in chromosome structure and function.黏连蛋白的调控及其在染色体结构和功能中的作用。
Curr Opin Genet Dev. 2024 Apr;85:102159. doi: 10.1016/j.gde.2024.102159. Epub 2024 Feb 20.
4
Novel Insights into the Initiation, Evolution, and Progression of Multiple Myeloma by Multi-Omics Investigation.多组学研究对多发性骨髓瘤起始、演变和进展的新见解
Cancers (Basel). 2024 Jan 24;16(3):498. doi: 10.3390/cancers16030498.
5
Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis.胶质母细胞瘤铁死亡的三维基因调控网络。
Int J Mol Sci. 2023 Oct 6;24(19):14945. doi: 10.3390/ijms241914945.
6
Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins.深入了解 Curaxin CBL0137 表观遗传活性的机制：诱导 DNA 去甲基化和抑制 BET 家族蛋白。
Int J Mol Sci. 2023 Aug 17;24(16):12874. doi: 10.3390/ijms241612874.
7
Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters.多柔比星改变活性启动子周围基因组的空间组织。
Cells. 2023 Aug 4;12(15):2001. doi: 10.3390/cells12152001.
8
Epigenetically programmed resistance to chemo- and immuno-therapies.表观遗传编程的化疗和免疫治疗耐药性。
Adv Cancer Res. 2023;158:41-71. doi: 10.1016/bs.acr.2022.12.001. Epub 2023 Jan 27.
9
The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation.癌细胞中程序性死亡受体配体1（PD-L1）和程序性死亡受体配体2（PD-L2）的产生：从核染色质重排到细胞外呈现
Acta Pharm Sin B. 2022 Mar;12(3):1041-1053. doi: 10.1016/j.apsb.2021.09.010. Epub 2021 Sep 16.
10
3D chromatin architecture and transcription regulation in cancer.癌症中的 3D 染色质结构和转录调控。
J Hematol Oncol. 2022 May 4;15(1):49. doi: 10.1186/s13045-022-01271-x.
本文引用的文献
1
Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation.FACT对染色质稳定性的维持对于恶性转化至关重要。
iScience. 2020 Jun 26;23(6):101177. doi: 10.1016/j.isci.2020.101177. Epub 2020 May 18.
2
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells.BORIS 促进治疗抵抗性癌细胞中的染色质调控相互作用。
Nature. 2019 Aug;572(7771):676-680. doi: 10.1038/s41586-019-1472-0. Epub 2019 Aug 7.
3
Spatial chromatin architecture alteration by structural variations in human genomes at the population scale.人群水平人类基因组结构变异导致的空间染色质结构改变。
Genome Biol. 2019 Jul 30;20(1):148. doi: 10.1186/s13059-019-1728-x.
4
Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia.CBL0137 对 MLL 重排白血病的强效抗白血病活性。
Int J Cancer. 2020 Apr 1;146(7):1902-1916. doi: 10.1002/ijc.32582. Epub 2019 Aug 8.
5
High-throughput identification of human SNPs affecting regulatory element activity.高通量鉴定影响调控元件活性的人类 SNPs。
Nat Genet. 2019 Jul;51(7):1160-1169. doi: 10.1038/s41588-019-0455-2. Epub 2019 Jun 28.
6
Principles of genome folding into topologically associating domains.基因组折叠成拓扑关联域的原则。
Sci Adv. 2019 Apr 10;5(4):eaaw1668. doi: 10.1126/sciadv.aaw1668. eCollection 2019 Apr.
7
Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.蛋白质基因组学和 Hi-C 揭示了高超二倍体儿童急性淋巴细胞白血病中的转录失调。
Nat Commun. 2019 Apr 3;10(1):1519. doi: 10.1038/s41467-019-09469-3.
8
The anti-cancer drugs curaxins target spatial genome organization.抗癌药物 curaxin 靶向空间基因组组织。
Nat Commun. 2019 Mar 29;10(1):1441. doi: 10.1038/s41467-019-09500-7.
9
Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression.单条染色体非整倍性引起全基因组核组织和基因表达的广泛扰乱。
Neoplasia. 2019 Apr;21(4):401-412. doi: 10.1016/j.neo.2019.02.003. Epub 2019 Mar 22.
10
Analyzing the 3D chromatin organization coordinating with gene expression regulation in B-cell lymphoma.分析B细胞淋巴瘤中与基因表达调控相关的三维染色质组织。
BMC Med Genomics. 2019 Mar 20;11(Suppl 7):127. doi: 10.1186/s12920-018-0437-8.
Zotero 插件