Kantidze Omar L, Gurova Katerina V, Studitsky Vasily M, Razin Sergey V
Laboratory of Genome Stability, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Trends Mol Med. 2020 Feb;26(2):141-149. doi: 10.1016/j.molmed.2019.09.011. Epub 2019 Oct 31.
The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers. We discuss potential connections of the 3D genome and cancer transcriptional addiction phenomenon as well as molecular mechanisms of action of 3D genome-disrupting drugs. Finally, we highlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affecting 3D genome organization.
三维基因组组织在基因表达精确调控中的作用已得到充分证实。因此，三维基因组改变与疾病发展之间的机制联系正变得越来越明显。这篇观点文章简要介绍了我们目前对与癌症相关的三维基因组改变的理解。我们讨论了三维基因组与癌症转录成瘾现象的潜在联系以及三维基因组破坏药物的分子作用机制。最后，我们强调了发现第一种强烈影响三维基因组组织的药物所引发的问题和观点。
