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植物反应组学:一个用于比较通路分析的知识库和资源。

Plant Reactome: a knowledgebase and resource for comparative pathway analysis.

机构信息

Department of Botany & Plant Pathology, Oregon State University, Corvallis, OR, USA.

NYU School of Medicine, New York, NY, USA.

出版信息

Nucleic Acids Res. 2020 Jan 8;48(D1):D1093-D1103. doi: 10.1093/nar/gkz996.

DOI:10.1093/nar/gkz996
PMID:31680153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7145600/
Abstract

Plant Reactome (https://plantreactome.gramene.org) is an open-source, comparative plant pathway knowledgebase of the Gramene project. It uses Oryza sativa (rice) as a reference species for manual curation of pathways and extends pathway knowledge to another 82 plant species via gene-orthology projection using the Reactome data model and framework. It currently hosts 298 reference pathways, including metabolic and transport pathways, transcriptional networks, hormone signaling pathways, and plant developmental processes. In addition to browsing plant pathways, users can upload and analyze their omics data, such as the gene-expression data, and overlay curated or experimental gene-gene interaction data to extend pathway knowledge. The curation team actively engages researchers and students on gene and pathway curation by offering workshops and online tutorials. The Plant Reactome supports, implements and collaborates with the wider community to make data and tools related to genes, genomes, and pathways Findable, Accessible, Interoperable and Re-usable (FAIR).

摘要

植物反应组数据库(https://plantreactome.gramene.org)是 Gramene 项目的一个开源、比较的植物途径知识库。它使用水稻作为参考物种,通过使用 Reactome 数据模型和框架进行基因同源性投影,对途径进行人工策展,并将途径知识扩展到另外 82 种植物物种。它目前拥有 298 个参考途径,包括代谢和运输途径、转录网络、激素信号途径和植物发育过程。除了浏览植物途径外,用户还可以上传和分析他们的组学数据,如基因表达数据,并覆盖策管或实验基因-基因相互作用数据,以扩展途径知识。策展团队通过提供研讨会和在线教程,积极与研究人员和学生合作进行基因和途径策展。植物反应组数据库支持、实现并与更广泛的社区合作,使与基因、基因组和途径相关的数据和工具具有可发现性、可访问性、互操作性和可重用性(FAIR)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/bb40ffae72ed/gkz996fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/aaaf2c559c80/gkz996fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/45a00135de99/gkz996fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/bb40ffae72ed/gkz996fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/aaaf2c559c80/gkz996fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/45a00135de99/gkz996fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef5f/7145600/bb40ffae72ed/gkz996fig3.jpg

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