微生物组、自身免疫性疾病和 HIV 感染：是敌是友？
Microbiome, Autoimmune Diseases and HIV Infection: Friends or Foes?
机构信息
Department of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, 00185 Rome, Italy.
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome Italy.
出版信息
Nutrients. 2019 Nov 2;11(11):2629. doi: 10.3390/nu11112629.
Several studies highlighted the importance of the interaction between microbiota and the immune system in the development and maintenance of the homeostasis of the human organism. Dysbiosis is associated with proinflammatory and pathological state-like metabolic diseases, autoimmune diseases and HIV infection. In this review, we discuss the current understanding of the possible role of dysbiosis in triggering and/or exacerbating symptoms of autoimmune diseases and HIV infection. There are no data about the influence of the microbiome on the development of autoimmune diseases during HIV infection. We can hypothesize that untreated patients may be more susceptible to the development of autoimmune diseases, due to the presence of dysbiosis. Eubiosis, re-established by probiotic administration, can be used to reduce triggers for autoimmune diseases in untreated HIV patients, although clinical studies are needed to evaluate the role of the microbiome in autoimmune diseases in HIV patients.
多项研究强调了微生物群和免疫系统在人类机体的稳态的发展和维持中的相互作用的重要性。 肠道菌群失调与促炎和类似病理状态的代谢性疾病、自身免疫性疾病和 HIV 感染有关。 在这篇综述中，我们讨论了对肠道菌群失调在触发和/或加重自身免疫性疾病和 HIV 感染症状中的可能作用的现有认识。 关于微生物组对 HIV 感染期间自身免疫性疾病发展的影响尚无数据。 我们可以假设，由于存在肠道菌群失调，未治疗的患者可能更容易发生自身免疫性疾病。 通过益生菌的给予来重建正常的微生物群，可用于减少未治疗的 HIV 患者的自身免疫性疾病的诱因，尽管需要临床研究来评估微生物组在 HIV 患者中的自身免疫性疾病中的作用。
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