Institute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
University Clinic and Outpatient Clinic for Cardiac Surgery,Middle German Heart Centre at the University Hospital Halle, Halle, Germany.
BMC Geriatr. 2019 Nov 4;19(1):299. doi: 10.1186/s12877-019-1323-8.
Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.
AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.
Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age.
We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.
晚期糖基化终产物（AGEs）是蛋白质或氨基酸的修饰产物，随着年龄相关疾病的发生，其产生和积累逐渐增加。最近的研究表明，AGEs 与其可溶性受体（sRAGE）的比值比各自单独作为与年龄相关疾病的生物标志物更为准确。我们旨在研究其是否也适用于广泛年龄范围内的身体机能。
在 CARLA 研究中，测量了 967 名男性和 812 名女性（45-83 岁）的 AGEs 和 sRAGE 水平以及身体机能（SF-12 问卷）。我们使用有序逻辑回归，在按性别和年龄分层的模型中，检验 AGEs、sRAGE 和 AGE/sRAGE 比值与身体机能之间的关联。
仅在女性中，较高水平的 AGEs 和 AGE/sRAGE 比值与较低的身体机能相关，即使考虑了经典的生活方式和与年龄相关的因素（教育、BMI、吸烟、饮酒、饮食、肌酐清除率、糖尿病、降脂和降压药物）（比值比（OR）=0.86，95%置信区间=0.74-0.98 和 OR=0.86，95%CI=0.75-0.98 分别为 AGEs 和 AGE/sRAGE 比值）。我们没有发现年龄之间存在显著差异。
我们表明，身体机能与 AGEs 和 AGE/sRAGE 之间存在性别特异性关联，但后者与身体机能的关联没有更强。需要进一步研究这种关联的病理生理学。
