Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland
INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland.
Antimicrob Agents Chemother. 2020 Jan 27;64(2). doi: 10.1128/AAC.01700-19.
A carbapenem-resistant isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β-lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from The gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the complex, including (PFM-2) and (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.
从鸡肉中分离出一株耐碳青霉烯类的 ，该 产生了新型碳青霉烯酶 PFM-1。这种 B2 型金属β-内酰胺酶与 中的β-内酰胺酶 Sfh-1 有 71%的氨基酸同源性。 基因位于染色体上，可能是通过水平基因转移获得的。在 复合体所属的细菌种属中发现了与 PFM-1 氨基酸序列相似度为 90%到 92%的变体，包括 (PFM-2)和 (PFM-3)，这表明这些种属是 PFM 样编码基因的储存库。
