牙周正畸联合治疗对牙周炎患者NOD样受体蛋白3和高迁移率族蛋白B1表达的影响及其临床意义
Effect of combined periodontal-orthodontic treatment on NOD-like receptor protein 3 and high mobility group box-1 expressions in patients with periodontitis and its clinical significance.
作者信息
Yu Lihua, Zhou Chen, Wei Zicheng, Shi Zhanai
机构信息
Department of Stomatology, Hospital of Nanjing University of Science and Technology, Nanjing.
Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangnan University, The Fourth People's Hospital of Wuxi City, Wuxi, Jiangsu, China.
出版信息
Medicine (Baltimore). 2019 Nov;98(44):e17724. doi: 10.1097/MD.0000000000017724.
To investigate the effect of combined periodontal-orthodontic treatment on the gingival crevicular fluid (GCF) levels of high mobility group box-1 (HMGB1) and NOD-like receptor protein 3 (NLRP3) in chronic periodontitis.A total of 60 patients with periodontitis who received combined periodontal-orthodontic treatment and 32 healthy individuals as normal controls were recruited in this study. Periodontal parameters were recorded. Enzyme-linked immunosorbent assay (ELISA) was used to examine GCF levels of HMGB1 and NLRP3.The periodontal parameters and GCF levels of HMGB1 and NLRP3 in periodontitis patients were significantly higher before treatment, and observably decreased after 6 months of treatment as compared with the healthy group. However, significant positive correlations were observed between HMGB1, NLRP3, and periodontal parameters in chronic periodontitis patients.Patients with chronic periodontitis showed higher levels of HMGB1 and NLRP3 in GCF.
探讨牙周正畸联合治疗对慢性牙周炎患者龈沟液（GCF）中高迁移率族蛋白B1（HMGB1）和NOD样受体蛋白3（NLRP3）水平的影响。本研究共纳入60例接受牙周正畸联合治疗的牙周炎患者和32名健康个体作为正常对照。记录牙周参数。采用酶联免疫吸附测定（ELISA）法检测HMGB1和NLRP3的GCF水平。牙周炎患者治疗前的牙周参数以及HMGB1和NLRP3 的GCF水平显著高于健康组，治疗6个月后明显降低。然而，慢性牙周炎患者的HMGB1、NLRP3与牙周参数之间存在显著正相关。慢性牙周炎患者的GCF中HMGB1和NLRP3水平较高。
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