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对甲病毒感染产生交叉反应的细胞毒性T细胞。

Cross-reactive cytotoxic T cells to alphavirus infection.

作者信息

Mullbacher A, Marshall I D, Blanden R V

出版信息

Scand J Immunol. 1979;10(4):291-6. doi: 10.1111/j.1365-3083.1979.tb01353.x.

DOI:10.1111/j.1365-3083.1979.tb01353.x
PMID:316916
Abstract

Secondary Tc cells immune to alphaviruses (BEB, SIN and SFV) cross-react between serologically defined subgroups at the level of target lysis and at the level of induction of response. Despite this apparently complete Tc cell cross-reactivity between BEB, SIN and SFV, antisera raised against BEB and SIN showed virus specificity in their ability to block Tc cell-mediated lysis of alphavirus-infected targets. This result suggests that Tc cells recognize the same viral antigen molecule as antibodies, but with less specificity. Other possible interpretations are discussed.

摘要

对甲病毒(BEB、SIN和SFV)免疫的二级Tc细胞在靶细胞裂解水平和反应诱导水平上,在血清学定义的亚组之间发生交叉反应。尽管BEB、SIN和SFV之间的Tc细胞交叉反应明显完全,但针对BEB和SIN产生的抗血清在阻断Tc细胞介导的甲病毒感染靶细胞裂解的能力上显示出病毒特异性。这一结果表明,Tc细胞识别的病毒抗原分子与抗体相同,但特异性较低。文中讨论了其他可能的解释。

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