不同的D末端依赖性抗原决定簇可被针对流感病毒和贝巴鲁病毒的H-2限制性细胞毒性T细胞识别。
Different D end-dependent antigenic determinants are recognized by H-2-restricted cytotoxic T cells specific for influenza and Bebaru viruses.
作者信息
Blanden R V, Müllbacher A, Ashman R B
出版信息
J Exp Med. 1979 Jul 1;150(1):166-3. doi: 10.1084/jem.150.1.166.
Abstract
Two different BALB/c anti-CBA (H-2k)monoclonal antibodies that bind to Kk and Dk antigens blocked Tc cell-mediated lysis of L929 (Kk, Dk) target cells, but with quite different specificity. One antibody (30R3) powerfully blocked Kk-specific lysis mediated by alloreactive or Kk-restricted Tc cells immune to ectromelia, Sendai, or influenza viruses. The other antibody (27R9) blocked these anti-Kk Tc cells much less than 30R3, but in contrast, 27R9 blocked anti-Dk lysis much more than 30R3. Most importantly, 27R9 strongly blocked Dk-restricted anti-influenza Tc cells, but did not significantly block Dk-restricted anti-Bebaru (BEB) lysis. This result indicated that different H-2 determinants coded in the D end of H-2k were recognized by influenza-and BEB-immune Tc cells. These determinants may be carried on two different molecules coded by the H-2D and H-2L loci, but other possibilities are not yet excluded.
摘要
两种不同的BALB/c抗CBA（H-2k）单克隆抗体，它们与Kk和Dk抗原结合，可阻断Tc细胞介导的L929（Kk，Dk）靶细胞裂解，但特异性差异很大。一种抗体（30R3）能有效阻断由同种反应性或对痘苗病毒、仙台病毒或流感病毒免疫的Kk限制性Tc细胞介导的Kk特异性裂解。另一种抗体（27R9）对这些抗Kk Tc细胞的阻断作用远小于30R3，但相比之下，27R9对抗Dk裂解的阻断作用远大于30R3。最重要的是，27R9强烈阻断Dk限制性抗流感Tc细胞，但对Dk限制性抗贝巴鲁（BEB）裂解无明显阻断作用。这一结果表明，流感免疫和BEB免疫的Tc细胞识别H-2k的D端编码的不同H-2决定簇。这些决定簇可能由H-2D和H-2L基因座编码的两种不同分子携带，但其他可能性尚未排除。
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本文引用的文献
1
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。通过使用抗H-2和抗Ia抗体证实对三硝基苯基修饰的H-2抗原反应的遗传控制。
J Exp Med. 1976 Jan 1;143(1):211-7. doi: 10.1084/jem.143.1.211.
2
H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.病毒特异性T细胞介导的细胞溶解对H-2相容性的要求。所涉及的H-2K结构由H-2Kb突变小鼠定义的单个顺反子编码。
J Exp Med. 1976 Feb 1;143(2):437-43. doi: 10.1084/jem.143.2.437.
3
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
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