Zhu Guo-Hua, Sun Xi-Peng, Liu Zhi, Fan Zhen-Xing, Wang Yan-Ling, Tan Jing, Li Jing, Hua Qi
Department of Cardiology, Xuanwu Hospital Capital Medical University, Beijing, China.
J Geriatr Cardiol. 2019 Oct;16(10):775-781. doi: 10.11909/j.issn.1671-5411.2019.10.004.
Elevated serum phosphorus levels may be associated with adverse outcomes in cardiovascular disease. This study aimed to investigate the relation between serum phosphorus levels and risk of all-cause mortality in Chinese patients with ST-segment elevation myocardial infarction (STEMI) who had preserved renal function at baseline.
We enrolled patients with STEMI who had preserved renal function at baseline in Xuanwu Hospital from January 2011 to December 2016. Those patients were divided into four groups based on serum phosphorus levels. All-cause mortality rates were compared between groups. Mean duration of follow up was 54.6 months. We used Cox proportional-hazards models to examine the relation between serum phosphorus levels and all-cause mortality after adjustment for potential confounders.
1989 patients were involved and 211 patients (10.6%) died during follow-up. Based on serum phosphorus levels, patients were categorized into the following groups: < 2.50 mg/dL ( = 89), 2.51-3.50 mg/dL ( = 1066), 3.51-4.50 mg/dL ( = 672) and > 4.50 mg/dL ( = 162), respectively. The lowest mortality occurred in patients with serum phosphorus levels between 2.51-3.50 mg/dL, with a multivariable-adjusted hazard ratio of 1.19 (95% CI: 0.64-1.54), 1.37 (95% CI: 1.22-1.74), and 1.46 (95% CI: 1.35-1.83) in patients with serum phosphorus levels of < 2.50 mg/dL, 3.51-4.50 mg/dL and > 4.50 mg/dL, respectively.
Elevated serum phosphorus levels were associated with all-cause mortality in Chinese patients with STEMI who had preserved renal function at baseline.
血清磷水平升高可能与心血管疾病的不良结局相关。本研究旨在探讨基线肾功能正常的中国ST段抬高型心肌梗死（STEMI）患者血清磷水平与全因死亡率风险之间的关系。
我们纳入了2011年1月至2016年12月在宣武医院基线肾功能正常的STEMI患者。根据血清磷水平将这些患者分为四组。比较各组的全因死亡率。平均随访时间为54.6个月。我们使用Cox比例风险模型在调整潜在混杂因素后检验血清磷水平与全因死亡率之间的关系。
共纳入1989例患者，随访期间211例患者（10.6%）死亡。根据血清磷水平，患者分为以下几组：<2.50mg/dL（n = 89）、2.51 - 3.50mg/dL（n = 1066）、3.51 - 4.50mg/dL（n = 672）和>4.50mg/dL（n = 162）。血清磷水平在2.51 - 3.50mg/dL之间的患者死亡率最低，血清磷水平<2.50mg/dL、3.51 - 4.50mg/dL和>4.50mg/dL的患者多变量调整后的风险比分别为1.19（95%CI：0.64 - 1.54）、1.37（95%CI：1.22 - 1.74）和1.46（95%CI：1.35 - 1.83）。
基线肾功能正常的中国STEMI患者血清磷水平升高与全因死亡率相关。
