Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität München, Theresienstraße 37, D-80333 Munich, Germany.
Phys Rev Lett. 2019 Oct 25;123(17):178101. doi: 10.1103/PhysRevLett.123.178101.
Some of the key proteins essential for important cellular processes are capable of recruiting other proteins from the cytosol to phospholipid membranes. The physical basis for this cooperativity of binding is, surprisingly, still unclear. Here, we suggest a general feedback mechanism that explains cooperativity through mechanochemical coupling mediated by the mechanical properties of phospholipid membranes. Our theory predicts that protein recruitment, and therefore also protein pattern formation, involves membrane deformation and is strongly affected by membrane composition.
一些对重要细胞过程至关重要的关键蛋白能够从细胞质中将其他蛋白招募到磷脂膜上。这种结合协同性的物理基础仍然令人惊讶地不清楚。在这里，我们提出了一个一般的反馈机制，该机制通过磷脂膜的机械特性介导的机械化学耦联来解释协同性。我们的理论预测，蛋白质的招募，因此也包括蛋白质的模式形成，涉及到膜的变形，并且受到膜成分的强烈影响。
